Open Label Vancomycin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Improved Colonic Disease Activity and Associations With Changes in Host-Microbiome-Metabolomic Signatures.

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Title: Open Label Vancomycin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Improved Colonic Disease Activity and Associations With Changes in Host-Microbiome-Metabolomic Signatures.
Authors: Quraishi MN; Department of Gastroenterology, University Hospitals Birmingham, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; University of Birmingham Microbiome Treatment Centre, University of Birmingham, Birmingham, UK.; Liver Unit, University Hospitals Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Gastroenterology, Inflammatory Bowel Disease Center, Sheikh Shakhbout Medical City, Abu Dhabi, UAE., Cheesbrough J; Department of Gastroenterology, University Hospitals Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Rimmer P; Department of Gastroenterology, University Hospitals Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Mullish BH; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Department of Gastroenterology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.; Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK., Sharma N; Department of Gastroenterology, University Hospitals Birmingham, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; University of Birmingham Microbiome Treatment Centre, University of Birmingham, Birmingham, UK., Efstathiou E; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Acharjee A; Institute of Translational Medicine, University Hospitals Birmingham, Birmingham, UK.; MRC Health Data Research UK (HDR UK), Birmingham, UK., Gkoutus G; Institute of Translational Medicine, University Hospitals Birmingham, Birmingham, UK.; MRC Health Data Research UK (HDR UK), Birmingham, UK., Patel A; Liver Unit, University Hospitals Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Marchesi JR; Department of Gastroenterology, Inflammatory Bowel Disease Center, Sheikh Shakhbout Medical City, Abu Dhabi, UAE., Camuzeaux S; MRC Health Data Research UK (HDR UK), Birmingham, UK., Chappell K; MRC Health Data Research UK (HDR UK), Birmingham, UK., Valdivia-Garcia MA; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Section of Bioanalytical Chemistry, IRDB Building, Imperial College London, London, UK., Ferguson J; Liver Unit, University Hospitals Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Brookes MJ; Department of Gastroenterology, University of Wolverhampton, Wolverhampton, UK., Walmsley M; PSC Support, Oxford, UK., Rossiter AE; Institute of Microbiology and Infection, University of Birmingham, UK., van Schaik W; Institute of Microbiology and Infection, University of Birmingham, UK., McInnes RS; Institute of Microbiology and Infection, University of Birmingham, UK., Cooney R; Department of Gastroenterology, University Hospitals Birmingham, Birmingham, UK., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Beggs AD; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; University of Birmingham Microbiome Treatment Centre, University of Birmingham, Birmingham, UK., Iqbal TH; Department of Gastroenterology, University Hospitals Birmingham, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; University of Birmingham Microbiome Treatment Centre, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, UK., Trivedi PJ; Liver Unit, University Hospitals Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Source: Journal of Crohn's & colitis [J Crohns Colitis] 2025 Feb 04; Vol. 19 (2).
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE
Database: MEDLINE Ultimate
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