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Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.

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Title: Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.
Authors: Weinberg J; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Liu KH; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Lee CM; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Crandall WJ; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Cuevas AR; Department of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia, USA., Druzak SA; Department of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia, USA., Morgan ET; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA., Jarrell ZR; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Ortlund EA; Department of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia, USA., Martin GS; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Singer G; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Strobel FH; Department of Chemistry, Emory University, Atlanta, Georgia, USA., Go YM; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Jones DP; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: dpjones@emory.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Jan; Vol. 301 (1), pp. 108074. Date of Electronic Publication: 2024 Dec 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.
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  Data: <searchLink fieldCode="AU" term="%22Weinberg+J%22">Weinberg J</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Liu+KH%22">Liu KH</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Lee+CM%22">Lee CM</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Crandall+WJ%22">Crandall WJ</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Cuevas+AR%22">Cuevas AR</searchLink>; Department of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Druzak+SA%22">Druzak SA</searchLink>; Department of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+ET%22">Morgan ET</searchLink>; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Jarrell+ZR%22">Jarrell ZR</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Ortlund+EA%22">Ortlund EA</searchLink>; Department of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Martin+GS%22">Martin GS</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Singer+G%22">Singer G</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Strobel+FH%22">Strobel FH</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Go+YM%22">Go YM</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DP%22">Jones DP</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: dpjones@emory.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Jan; Vol. 301 (1), pp. 108074. <i>Date of Electronic Publication: </i>2024 Dec 13.
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              Text: 2025 Jan
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