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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.

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Title: Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.
Authors: Lehrich BM; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Delgado ER; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yasaka TM; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Liu S; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Cao C; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liu Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Taheri M; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Guan X; Translational Medicine, Genentech Inc., San Francisco, CA, USA., Koeppen H; Translational Medicine, Genentech Inc., San Francisco, CA, USA., Singh S; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liu JJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Singh-Varma A; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Krutsenko Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Poddar M; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hitchens TK; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Foley LM; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Liang B; Hepatic Surgery Center, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Rialdi A; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY., Rai RP; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Patel P; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Riley M; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bell A; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Raeman R; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Dadali T; Alnylam Pharmaceuticals, Boston, MA, USA., Luke JJ; UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA., Guccione E; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY., Ebrahimkhani MR; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lujambio A; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY., Chen X; Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Maier M; Alnylam Pharmaceuticals, Boston, MA, USA., Wang Y; Translational Medicine, Genentech Inc., San Francisco, CA, USA., Broom W; Alnylam Pharmaceuticals, Boston, MA, USA., Tao J; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Monga SP; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Source: Research square [Res Sq] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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