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Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.

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Title: Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.
Authors: Garnsey MR; Pfizer, Inc., Cambridge, MA, 02139, USA. michelle.garnsey@pfizer.com., Wang Y; Pfizer, Inc., Cambridge, MA, 02139, USA., Edmonds DJ; Pfizer, Inc., Cambridge, MA, 02139, USA., Sammons MF; Pfizer, Inc., Cambridge, MA, 02139, USA., Reidich B; Pfizer, Inc., Cambridge, MA, 02139, USA., Ahn Y; Pfizer, Inc., Cambridge, MA, 02139, USA., Ashkenazi Y; Pfizer, Inc., Groton, CT, 06340, USA., Carlo A; Pfizer, Inc., Groton, CT, 06340, USA., Cerny MA; Pfizer, Inc., Groton, CT, 06340, USA., Coffman KJ; Pfizer, Inc., Groton, CT, 06340, USA., Culver JA; Pfizer, Inc., Cambridge, MA, 02139, USA., Dechert Schmitt AM; Pfizer, Inc., Groton, CT, 06340, USA., Eng H; Pfizer, Inc., Groton, CT, 06340, USA., Fisher EL; Pfizer, Inc., Groton, CT, 06340, USA., Gutierrez JA; Pfizer, Inc., Cambridge, MA, 02139, USA., James L; Pfizer, Inc., Cambridge, MA, 02139, USA., Jordan S; Pfizer, Inc., Groton, CT, 06340, USA., Kohrt JT; Pfizer, Inc., Groton, CT, 06340, USA., Kramer M; Pfizer, Inc., Cambridge, MA, 02139, USA., LaChapelle EA; Pfizer, Inc., Groton, CT, 06340, USA., Lee JC; Pfizer, Inc., Groton, CT, 06340, USA., Lee J; Pfizer, Inc., Groton, CT, 06340, USA., Li D; Pfizer, Inc., Cambridge, MA, 02139, USA., Li Z; Pfizer, Inc., Cambridge, MA, 02139, USA., Liu S; Pfizer, Inc., Groton, CT, 06340, USA., Liu J; Pfizer, Inc., Groton, CT, 06340, USA., Magee TV; Pfizer, Inc., Cambridge, MA, 02139, USA., Miller MR; Pfizer, Inc., Cambridge, MA, 02139, USA., Moran M; Pfizer, Inc., Groton, CT, 06340, USA., Nason DM; Pfizer, Inc., Groton, CT, 06340, USA., Nedoma NL; Pfizer, Inc., Groton, CT, 06340, USA., O'Neil SV; Pfizer, Inc., Groton, CT, 06340, USA., Piotrowski MA; Pfizer, Inc., Groton, CT, 06340, USA., Racich J; Pfizer, Inc., Groton, CT, 06340, USA., Sommese RF; Pfizer, Inc., Groton, CT, 06340, USA., Stevens LM; Pfizer, Inc., Groton, CT, 06340, USA., Wright AS; Pfizer, Inc., Groton, CT, 06340, USA., Xiao J; Pfizer, Inc., Groton, CT, 06340, USA., Zhang L; Pfizer, Inc., Cambridge, MA, 02139, USA., Zhou D; Pfizer, Inc., Groton, CT, 06340, USA., Barrandon O; Pfizer, Inc., Cambridge, MA, 02139, USA., Clasquin MF; Pfizer, Inc., Cambridge, MA, 02139, USA. michelle.clasquin@pfizer.com.
Source: Nature communications [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 297. Date of Electronic Publication: 2025 Jan 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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