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Efficacy and Limitations of Continuous Local Antibiotic Perfusion in Treating Surgical Site Infections Following Instrumented Spinal Surgery: A Retrospective Multicenter Study.

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Title: Efficacy and Limitations of Continuous Local Antibiotic Perfusion in Treating Surgical Site Infections Following Instrumented Spinal Surgery: A Retrospective Multicenter Study.
Authors: Takahashi H; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. hirochann@syd.odn.ne.jp., Okuyama K; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Toki Y; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Funayama T; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Noguchi H; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Miura K; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Gamada H; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Okuwaki S; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Ogata Y; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Sakashita K; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Sunami T; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Nakagawa T; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Fujii K; Department of Orthopaedic Surgery, Showa General Hospital, 8-1-1, Hanakoganei, Kodaira City, Tokyo, 187-0002, Japan., Ishikawa T; Department of Orthopaedic Surgery, Sanmu Medical Center, 167, Naruto, Sanmu, Chiba, 289-1326, Japan., Kim G; Emergency Medical Center, Tokyo Metropolitan Bokutoh Hospital, 4-23-15, Kotobashi, Sumidaku, Tokyo, 130-8575, Japan., Ota M; Department of Orthopaedic Surgery, Seirei Yokohama Hospital, 215, Iwaicho, Hodogayaku, Yokohama City, Kanagawa, 240-8521, Japan., Inada T; Department of Orthopaedic Surgery, Chiba Emergency and Psychiatric Medical Center, 6-1, Toyosuna, Mihamaku, Chiba, Chiba, 261-0024, Japan., Himeno D; Department of Orthopaedic Surgery, Chiba Emergency and Psychiatric Medical Center, 6-1, Toyosuna, Mihamaku, Chiba, Chiba, 261-0024, Japan.; Department of Orthopaedic Surgery, Chibanishi General Hospital, 107-1, Kanegasaku, Matsudo, Chiba, 270-2251, Japan., Takaoka H; Department of Orthopaedic Surgery, New Tokyo Hospital, 1271, Wanagaya, Matsudo, Chiba, 270-2232, Japan., Suzuki M; Department of Orthopaedic Surgery, Sanno Hospital, 166-2, Sannocho, Inageku, Chiba, Chiba, 263-0002, Japan., Maki S; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Inoue M; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Inage K; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Shiga Y; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Furuya T; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Eguchi Y; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Orita S; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Ohtori S; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan., Yamazaki M; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan., Koda M; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Source: Infectious diseases and therapy [Infect Dis Ther] 2025 Feb; Vol. 14 (2), pp. 421-431. Date of Electronic Publication: 2025 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Adis Country of Publication: New Zealand NLM ID: 101634499 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8229 (Print) Linking ISSN: 21936382 NLM ISO Abbreviation: Infect Dis Ther Subsets: PubMed not MEDLINE
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  Data: Efficacy and Limitations of Continuous Local Antibiotic Perfusion in Treating Surgical Site Infections Following Instrumented Spinal Surgery: A Retrospective Multicenter Study.
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  Data: <searchLink fieldCode="AU" term="%22Takahashi+H%22">Takahashi H</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. hirochann@syd.odn.ne.jp.<br /><searchLink fieldCode="AU" term="%22Okuyama+K%22">Okuyama K</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Toki+Y%22">Toki Y</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Funayama+T%22">Funayama T</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Noguchi+H%22">Noguchi H</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Miura+K%22">Miura K</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Gamada+H%22">Gamada H</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Okuwaki+S%22">Okuwaki S</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Ogata+Y%22">Ogata Y</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Sakashita+K%22">Sakashita K</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Sunami+T%22">Sunami T</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+T%22">Nakagawa T</searchLink>; Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Fujii+K%22">Fujii K</searchLink>; Department of Orthopaedic Surgery, Showa General Hospital, 8-1-1, Hanakoganei, Kodaira City, Tokyo, 187-0002, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+T%22">Ishikawa T</searchLink>; Department of Orthopaedic Surgery, Sanmu Medical Center, 167, Naruto, Sanmu, Chiba, 289-1326, Japan.<br /><searchLink fieldCode="AU" term="%22Kim+G%22">Kim G</searchLink>; Emergency Medical Center, Tokyo Metropolitan Bokutoh Hospital, 4-23-15, Kotobashi, Sumidaku, Tokyo, 130-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Ota+M%22">Ota M</searchLink>; Department of Orthopaedic Surgery, Seirei Yokohama Hospital, 215, Iwaicho, Hodogayaku, Yokohama City, Kanagawa, 240-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Inada+T%22">Inada T</searchLink>; Department of Orthopaedic Surgery, Chiba Emergency and Psychiatric Medical Center, 6-1, Toyosuna, Mihamaku, Chiba, Chiba, 261-0024, Japan.<br /><searchLink fieldCode="AU" term="%22Himeno+D%22">Himeno D</searchLink>; Department of Orthopaedic Surgery, Chiba Emergency and Psychiatric Medical Center, 6-1, Toyosuna, Mihamaku, Chiba, Chiba, 261-0024, Japan.; Department of Orthopaedic Surgery, Chibanishi General Hospital, 107-1, Kanegasaku, Matsudo, Chiba, 270-2251, Japan.<br /><searchLink fieldCode="AU" term="%22Takaoka+H%22">Takaoka H</searchLink>; Department of Orthopaedic Surgery, New Tokyo Hospital, 1271, Wanagaya, Matsudo, Chiba, 270-2232, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+M%22">Suzuki M</searchLink>; Department of Orthopaedic Surgery, Sanno Hospital, 166-2, Sannocho, Inageku, Chiba, Chiba, 263-0002, Japan.<br /><searchLink fieldCode="AU" term="%22Maki+S%22">Maki S</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+M%22">Inoue M</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Inage+K%22">Inage K</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Shiga+Y%22">Shiga Y</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Furuya+T%22">Furuya T</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi+Y%22">Eguchi Y</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.<br /><searchLink fieldCode="AU" term="%22Orita+S%22">Orita S</searchLink>; 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