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R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45 years: an open-label, partially blinded, phase 1-2a controlled human malaria infection study.

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Title: R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45 years: an open-label, partially blinded, phase 1-2a controlled human malaria infection study.
Authors: Venkatraman N; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Silman D; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Bellamy D; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Stockdale L; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Bowyer G; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Edwards NJ; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Griffiths O; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Lopez FR; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Powlson J; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Mair C; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Folegatti PM; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Datoo MS; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Morter R; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Minassian AM; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; Department of Biochemistry, University of Oxford, Oxford, UK., Poulton I; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Collins KA; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Brod F; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Angell-Manning P; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Berrie E; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Brendish N; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Glenn G; Novavax, Gaithersburg, MD, USA., Fries L; Novavax, Gaithersburg, MD, USA., Baum J; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Blagborough AM; Department of Pathology, University of Cambridge, Cambridge, UK., Roberts R; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Lawrie AM; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Angus B; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Lewis DJM; NIHR/Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, London, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Ewer KJ; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: katie.j.ewer@gsk.com., Hill AVS; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Source: The Lancet. Microbe [Lancet Microbe] 2025 Mar; Vol. 6 (3), pp. 100867. Date of Electronic Publication: 2025 Jan 10.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
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  Data: R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45 years: an open-label, partially blinded, phase 1-2a controlled human malaria infection study.
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  Data: <searchLink fieldCode="AU" term="%22Venkatraman+N%22">Venkatraman N</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Silman+D%22">Silman D</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bellamy+D%22">Bellamy D</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Stockdale+L%22">Stockdale L</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bowyer+G%22">Bowyer G</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+NJ%22">Edwards NJ</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Griffiths+O%22">Griffiths O</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lopez+FR%22">Lopez FR</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Powlson+J%22">Powlson J</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mair+C%22">Mair C</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Folegatti+PM%22">Folegatti PM</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Datoo+MS%22">Datoo MS</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morter+R%22">Morter R</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Minassian+AM%22">Minassian AM</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Poulton+I%22">Poulton I</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Collins+KA%22">Collins KA</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Brod+F%22">Brod F</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Angell-Manning+P%22">Angell-Manning P</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Berrie+E%22">Berrie E</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Brendish+N%22">Brendish N</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Glenn+G%22">Glenn G</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fries+L%22">Fries L</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Baum+J%22">Baum J</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Blagborough+AM%22">Blagborough AM</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+AM%22">Lawrie AM</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Angus+B%22">Angus B</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+DJM%22">Lewis DJM</searchLink>; NIHR/Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Faust+SN%22">Faust SN</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: katie.j.ewer@gsk.com.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
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  Data: <searchLink fieldCode="JN" term="%22101769019%22">The Lancet. Microbe</searchLink> [Lancet Microbe] 2025 Mar; Vol. 6 (3), pp. 100867. <i>Date of Electronic Publication: </i>2025 Jan 10.
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              Text: 2025 Mar
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