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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.

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Title: Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.
Authors: Glaviano A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy., Lau HS; Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Carter LM; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lee EHC; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Lam HY; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Okina E; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Tan DJJ; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; School of Chemical and Life Sciences, Singapore Polytechnic, Singapore, 139651, Singapore., Tan W; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; School of Chemical and Life Sciences, Singapore Polytechnic, Singapore, 139651, Singapore., Ang HL; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Carbone D; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy., Yee MY; Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore., Shanmugam MK; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Huang XZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Lim LHK; Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Immunology Program, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Huang RY; School of Medicine and Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore., Ungefroren H; First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, 23538, Lübeck, Germany., Giovannetti E; Department of Medical Oncology, Cancer Center Amsterdam, UMC, Vrije Universiteit, HV Amsterdam, 1081, Amsterdam, The Netherlands.; Cancer Pharmacology Lab, Fondazione Pisana Per La Scienza, 56017, San Giuliano, Italy., Tang DG; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.; Experimental Therapeutics (ET) Graduate Program, University at Buffalo & Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA., Bruno TC; Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Luo P; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Andersen MH; National Center for Cancer Immune Therapy, Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark., Qian BZ; Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan University, Shanghai, China., Ishihara J; Department of Bioengineering, Imperial College London, London, W12 0BZ, UK., Radisky DC; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, 32224, USA., Elias S; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Yadav S; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Kim M; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Robert C; Department of Cancer Medicine, Inserm U981, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.; Faculty of Medicine, University Paris-Saclay, Kremlin Bicêtre, Paris, France., Diana P; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy., Schalper KA; Department of Pathology, Yale School of Medicine, Yale University, New Haven, CT, USA., Shi T; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Merghoub T; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Department of Medicine, Parker Institute for Cancer Immunotherapy, Weill Cornell Medicine, New York, NY, USA., Krebs S; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kusumbe AP; Tissue and Tumor Microenvironment Group, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Davids MS; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Brown JR; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Kumar AP; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. apkumar@nus.edu.sg.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. apkumar@nus.edu.sg.
Source: Journal of hematology & oncology [J Hematol Oncol] 2025 Jan 13; Vol. 18 (1), pp. 6. Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article; Review
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Immunology Program, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+RY%22">Huang RY</searchLink>; School of Medicine and Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.<br /><searchLink fieldCode="AU" term="%22Ungefroren+H%22">Ungefroren H</searchLink>; First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, 23538, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Giovannetti+E%22">Giovannetti E</searchLink>; 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