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Novel Protective Role for Gut Microbiota-derived Metabolite PAGln in Doxorubicin-induced Cardiotoxicity.

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Title: Novel Protective Role for Gut Microbiota-derived Metabolite PAGln in Doxorubicin-induced Cardiotoxicity.
Authors: Huang J; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, 410013, Hunan, China., Hou X; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China., Zhou N; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China., Su N; Department of Ophthalmology, the First People's Hospital of Lanzhou City, Lanzhou, 730050, Gansu, China., Wei S; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China., Yang Y; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China., Sun T; School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China., Li G; Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, 410013, Hunan, China., Li W; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. liwq1204@csu.edu.cn.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China. liwq1204@csu.edu.cn., Zhang B; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. 505995@csu.edu.cn.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China. 505995@csu.edu.cn.
Source: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2026 Feb; Vol. 40 (1), pp. 65-80. Date of Electronic Publication: 2025 Jan 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel Protective Role for Gut Microbiota-derived Metabolite PAGln in Doxorubicin-induced Cardiotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, 410013, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Hou+X%22">Hou X</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zhou+N%22">Zhou N</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Su+N%22">Su N</searchLink>; Department of Ophthalmology, the First People's Hospital of Lanzhou City, Lanzhou, 730050, Gansu, China.<br /><searchLink fieldCode="AU" term="%22Wei+S%22">Wei S</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Sun+T%22">Sun T</searchLink>; School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, 410013, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. liwq1204@csu.edu.cn.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China. liwq1204@csu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. 505995@csu.edu.cn.; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China. 505995@csu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228712220%22">Cardiovascular drugs and therapy</searchLink> [Cardiovasc Drugs Ther] 2026 Feb; Vol. 40 (1), pp. 65-80. <i>Date of Electronic Publication: </i>2025 Jan 14.
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        Value: 10.1007/s10557-024-07665-y
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              Text: 2026 Feb
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              Y: 2026
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