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Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.

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Title: Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.
Authors: Snaebjornsson MT; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Poeller P; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Komkova D; Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany., Röhrig F; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Winkelkotte AM; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Chaves-Filho AB; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Al-Shami KM; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Caballero CD; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Koltsaki I; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Vogel FCE; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Frias-Soler RC; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Rudalska R; Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.; IFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Schwarz JD; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany., Wolf E; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.; Biochemical Institute, University of Kiel, Kiel, Germany., Dauch D; Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.; IFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), Tübingen, Germany., Steuer R; Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany.; Peter Debye Institute for Soft Matter Physics, Leipzig University, Leipzig, Germany., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. almut.schulze@dkfz-heidelberg.de.
Source: Nature metabolism [Nat Metab] 2025 Feb; Vol. 7 (2), pp. 348-366. Date of Electronic Publication: 2025 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.
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  Data: <searchLink fieldCode="AU" term="%22Snaebjornsson+MT%22">Snaebjornsson MT</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Poeller+P%22">Poeller P</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Komkova+D%22">Komkova D</searchLink>; Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Röhrig+F%22">Röhrig F</searchLink>; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlicker+L%22">Schlicker L</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Winkelkotte+AM%22">Winkelkotte AM</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chaves-Filho+AB%22">Chaves-Filho AB</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Shami+KM%22">Al-Shami KM</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Caballero+CD%22">Caballero CD</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Koltsaki+I%22">Koltsaki I</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Vogel+FCE%22">Vogel FCE</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Frias-Soler+RC%22">Frias-Soler RC</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rudalska+R%22">Rudalska R</searchLink>; Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.; IFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schwarz+JD%22">Schwarz JD</searchLink>; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+E%22">Wolf E</searchLink>; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.; Biochemical Institute, University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Dauch+D%22">Dauch D</searchLink>; Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.; IFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Steuer+R%22">Steuer R</searchLink>; Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany.; Peter Debye Institute for Soft Matter Physics, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+A%22">Schulze A</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. almut.schulze@dkfz-heidelberg.de.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2025 Feb; Vol. 7 (2), pp. 348-366. <i>Date of Electronic Publication: </i>2025 Jan 20.
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