Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition.

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Title: Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition.
Authors: Goldberg AR; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Dovas A; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Torres D; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Pereira B; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Viswanathan A; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Das Sharma S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Mela A; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Merricks EM; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Megino-Luque C; Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10027, USA., McInvale JJ; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Olabarria M; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Shokooh LA; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Zhao HT; Laboratory for Functional Optical Imaging, Zuckerman Mind Brain Behavior Institute, Departments of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, USA., Chen C; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Kotidis C; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Calvaresi P; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Banu MA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Razavilar A; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Sudhakar TD; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Saxena A; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Chokran C; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Mahajan A; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Xu W; Laboratory for Functional Optical Imaging, Zuckerman Mind Brain Behavior Institute, Departments of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, USA., Metz JB; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Bushong EA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA., Boassa D; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA., Ellisman MH; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA., Hillman EMC; Laboratory for Functional Optical Imaging, Zuckerman Mind Brain Behavior Institute, Departments of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, USA., Hargus G; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Bravo-Cordero JJ; Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10027, USA., McKhann GM 2nd; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Gill BJA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Rosenfeld SS; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA., Schevon CA; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA., Peterka DS; Irving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Canoll P; Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: pc561@cumc.columbia.edu.
Source: Neuron [Neuron] 2025 Mar 19; Vol. 113 (6), pp. 858-875.e10. Date of Electronic Publication: 2025 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition.
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