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Risk factors affecting polygenic score performance across diverse cohorts.

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Title: Risk factors affecting polygenic score performance across diverse cohorts.
Authors: Hui D; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Dudek S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Kiryluk K; Division of Nephrology, Department of Medicine, Columbia University, New York, United States., Walunas TL; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Kullo IJ; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States., Tiwari H; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, United States., Peterson JF; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States., Chung WK; Departments of Pediatrics and Medicine, Columbia University Irving Medical Center, Columbia University, New York, United States., Davis BH; Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, United States., Khan A; Division of Nephrology, Department of Medicine, Columbia University, New York, United States., Kottyan LC; The Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States., Limdi NA; Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, United States., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, United States., Puckelwartz MJ; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Weng C; Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University, New York, United States., Smith JL; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States., Karlson EW; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States., Jarvik GP; Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, United States., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Corporate Authors: Regeneron Genetics Center, Penn Medicine BioBank
Source: ELife [Elife] 2025 Jan 24; Vol. 12. Date of Electronic Publication: 2025 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hui+D%22">Hui D</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.<br /><searchLink fieldCode="AU" term="%22Dudek+S%22">Dudek S</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.<br /><searchLink fieldCode="AU" term="%22Kiryluk+K%22">Kiryluk K</searchLink>; Division of Nephrology, Department of Medicine, Columbia University, New York, United States.<br /><searchLink fieldCode="AU" term="%22Walunas+TL%22">Walunas TL</searchLink>; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.<br /><searchLink fieldCode="AU" term="%22Kullo+IJ%22">Kullo IJ</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.<br /><searchLink fieldCode="AU" term="%22Wei+WQ%22">Wei WQ</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States.<br /><searchLink fieldCode="AU" term="%22Tiwari+H%22">Tiwari H</searchLink>; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, United States.<br /><searchLink fieldCode="AU" term="%22Peterson+JF%22">Peterson JF</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States.<br /><searchLink fieldCode="AU" term="%22Chung+WK%22">Chung WK</searchLink>; Departments of Pediatrics and Medicine, Columbia University Irving Medical Center, Columbia University, New York, United States.<br /><searchLink fieldCode="AU" term="%22Davis+BH%22">Davis BH</searchLink>; Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, United States.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Division of Nephrology, Department of Medicine, Columbia University, New York, United States.<br /><searchLink fieldCode="AU" term="%22Kottyan+LC%22">Kottyan LC</searchLink>; The Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.<br /><searchLink fieldCode="AU" term="%22Limdi+NA%22">Limdi NA</searchLink>; Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, United States.<br /><searchLink fieldCode="AU" term="%22Feng+Q%22">Feng Q</searchLink>; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.<br /><searchLink fieldCode="AU" term="%22Puckelwartz+MJ%22">Puckelwartz MJ</searchLink>; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.<br /><searchLink fieldCode="AU" term="%22Weng+C%22">Weng C</searchLink>; Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University, New York, United States.<br /><searchLink fieldCode="AU" term="%22Smith+JL%22">Smith JL</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, United States.<br /><searchLink fieldCode="AU" term="%22Karlson+EW%22">Karlson EW</searchLink>; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.<br /><searchLink fieldCode="AU" term="%22Jarvik+GP%22">Jarvik GP</searchLink>; Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, United States.<br /><searchLink fieldCode="AU" term="%22Ritchie+MD%22">Ritchie MD</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
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