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Phosphodiesterase inhibition restores hypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study.

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Title: Phosphodiesterase inhibition restores hypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study.
Authors: Stacey BS; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK., Marley CJ; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK., Tsukamoto H; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.; Faculty of Sport Sciences, Waseda University, Shinjuku, Tokyo, Japan., Dawkins TG; School of Health and Exercise Sciences, University of British Columbia, Kelowna, Canada., Owens TS; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK., Calverley TA; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK., Fall L; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK., Iannetelli A; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK., Lewis I; University Hospital Wales, Cardiff, UK., Coulson JM; Clinical Pharmacology, Therapeutics & Toxicology, Cardiff University, Cardiff, UK., Stembridge M; Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK., Bailey DM; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.
Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2025 Jul; Vol. 45 (7), pp. 1343-1356. Date of Electronic Publication: 2025 Jan 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phosphodiesterase inhibition restores hypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study.
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  Data: <searchLink fieldCode="AU" term="%22Stacey+BS%22">Stacey BS</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.<br /><searchLink fieldCode="AU" term="%22Marley+CJ%22">Marley CJ</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.<br /><searchLink fieldCode="AU" term="%22Tsukamoto+H%22">Tsukamoto H</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.; Faculty of Sport Sciences, Waseda University, Shinjuku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Dawkins+TG%22">Dawkins TG</searchLink>; School of Health and Exercise Sciences, University of British Columbia, Kelowna, Canada.<br /><searchLink fieldCode="AU" term="%22Owens+TS%22">Owens TS</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.<br /><searchLink fieldCode="AU" term="%22Calverley+TA%22">Calverley TA</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.<br /><searchLink fieldCode="AU" term="%22Fall+L%22">Fall L</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.<br /><searchLink fieldCode="AU" term="%22Iannetelli+A%22">Iannetelli A</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+I%22">Lewis I</searchLink>; University Hospital Wales, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Coulson+JM%22">Coulson JM</searchLink>; Clinical Pharmacology, Therapeutics & Toxicology, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Stembridge+M%22">Stembridge M</searchLink>; Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Bailey+DM%22">Bailey DM</searchLink>; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.
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  Data: <searchLink fieldCode="JN" term="%228112566%22">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</searchLink> [J Cereb Blood Flow Metab] 2025 Jul; Vol. 45 (7), pp. 1343-1356. <i>Date of Electronic Publication: </i>2025 Jan 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8112566 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-7016 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220271678X%22">0271678X </searchLink><i>NLM ISO Abbreviation: </i>J Cereb Blood Flow Metab <i>Subsets: </i>MEDLINE
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