Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering.
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| Title: | Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering. |
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| Authors: | Liao Y; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Ma H; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Wang Z; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China., Wang S; Jecho Laboratories, Inc., Frederick, MD 21704., He Y; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China., Chang Y; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China., Zong H; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Tang H; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Wang L; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Ke Y; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Cai H; BioGeometry, Beijing 100083, China.; Mila-Québec AI Institute, Montréal, QC H2S 3H1, Canada.; Department of Computer Science and Operations Research, Université de Montréal, Montréal, QC H3T1J4, Canada., Li P; BioGeometry, Beijing 100083, China., Tang J; BioGeometry, Beijing 100083, China.; Mila-Québec AI Institute, Montréal, QC H2S 3H1, Canada.; Department of Decision Sciences, HEC Montréal, Montréal, QC H3T 2A7, Canada., Chen H; Jecho Laboratories, Inc., Frederick, MD 21704., Drelich A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555., Peng BH; Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX 77555., Hsu J; Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX 77555., Tat V; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555., Tseng CK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.; Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX 77555.; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.; Center for Biodefense and Emerging Disease, University of Texas Medical Branch, Galveston, TX 77555., Song J; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China., Yuan Y; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Wu M; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Liu J; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Yue Y; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Zhang X; Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, University People's Hospital, Zhengzhou, Henan 450003, China.; Clinical Research Service Center, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China., Wang Z; Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, University People's Hospital, Zhengzhou, Henan 450003, China.; Clinical Research Service Center, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China., Yang L; Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, University People's Hospital, Zhengzhou, Henan 450003, China.; Clinical Research Service Center, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China., Li J; Shuimu BioSciences Ltd. F4, Bio² Innovation Center, Life Science Park, Changping District, Beijing 102200, China., Ni X; Shuimu BioSciences Ltd. F4, Bio² Innovation Center, Life Science Park, Changping District, Beijing 102200, China., Li H; Shuimu BioSciences Ltd. F4, Bio² Innovation Center, Life Science Park, Changping District, Beijing 102200, China., Xiang Y; Shuimu BioSciences Ltd. F4, Bio² Innovation Center, Life Science Park, Changping District, Beijing 102200, China., Bian Y; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Zhang B; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Yin H; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Dimitrov DS; Center for Antibody Therapeutics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261., Gilly J; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China.; Jecho Laboratories, Inc., Frederick, MD 21704., Han L; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China.; Jecho Institute, Shanghai 200240, China., Jiang H; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China.; Jecho Laboratories, Inc., Frederick, MD 21704., Xie Y; Jecho Laboratories, Inc., Frederick, MD 21704.; Jecho Institute, Shanghai 200240, China., Zhu J; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China.; Jecho Laboratories, Inc., Frederick, MD 21704.; Jecho Institute, Shanghai 200240, China. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Feb 11; Vol. 122 (6), pp. e2406659122. Date of Electronic Publication: 2025 Feb 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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