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Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells.

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Title: Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells.
Authors: Lin CR; Department of Biochemistry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA., Hayek H; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA., Simborio H; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA., Karim L; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA., Bahmed K; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA., Bolla S; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA 19140, USA., Marchetti N; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA 19140, USA., Criner GJ; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA 19140, USA., Tian Y; Aging & Cardiovascular Discovery Center, Temple University, Philadelphia, PA 19140, USA.; Department of Cardiovascular Sciences, Temple University, Philadelphia, PA 19140, USA., Kosmider B; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA.
Source: Aging and disease [Aging Dis] 2025 Jan 14; Vol. 17 (1), pp. 367-382. Date of Electronic Publication: 2025 Jan 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: JKL International Country of Publication: United States NLM ID: 101540533 Publication Model: Electronic Cited Medium: Internet ISSN: 2152-5250 (Electronic) Linking ISSN: 21525250 NLM ISO Abbreviation: Aging Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells.
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  Data: <searchLink fieldCode="AU" term="%22Lin+CR%22">Lin CR</searchLink>; Department of Biochemistry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Hayek+H%22">Hayek H</searchLink>; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Simborio+H%22">Simborio H</searchLink>; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Karim+L%22">Karim L</searchLink>; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Bahmed+K%22">Bahmed K</searchLink>; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Bolla+S%22">Bolla S</searchLink>; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Marchetti+N%22">Marchetti N</searchLink>; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Criner+GJ%22">Criner GJ</searchLink>; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Aging & Cardiovascular Discovery Center, Temple University, Philadelphia, PA 19140, USA.; Department of Cardiovascular Sciences, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Kosmider+B%22">Kosmider B</searchLink>; Center for Inflammation and Lung Research, Temple University, Philadelphia, PA 19140, USA.; Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA 19140, USA.
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  Data: <searchLink fieldCode="JN" term="%22101540533%22">Aging and disease</searchLink> [Aging Dis] 2025 Jan 14; Vol. 17 (1), pp. 367-382. <i>Date of Electronic Publication: </i>2025 Jan 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22JKL+International%22">JKL International </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101540533 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2152-5250 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221525250%22">21525250 </searchLink><i>NLM ISO Abbreviation: </i>Aging Dis <i>Subsets: </i>MEDLINE
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        Value: 10.14336/AD.2024.1175
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        Text: English
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              Text: 2025 Jan 14
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