The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Saved in:
| Title: | The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model. |
|---|---|
| Authors: | Dusek J; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Mejdrová I; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Dohnalová K; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; First Faculty of Medicine, Charles University, Prague, Czech Republic., Smutny T; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Chalupsky K; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Krutakova M; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Skoda J; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Rashidian A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Tübingen, Germany., Pavkova I; Military Faculty of Medicine, University of Defence, Hradec Králové, Czech Republic., Škach K; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Hricová J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Chocholouskova M; Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic., Smutna L; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Kamaraj R; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Hroch M; Department of Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Leníček M; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic., Mičuda S; Institute of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Pijnenburg D; PamGene, 's-Hertogenbosch, The Netherlands., van Beuningen R; PamGene, 's-Hertogenbosch, The Netherlands., Holčapek M; Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic., Vítek L; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic.; 4th Department of Internal Medicine, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic., Ingelman-Sundberg M; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Burk O; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Tuebingen, Germany., Kronenberger T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Nencka R; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic. radim.nencka@uochb.cas.cz., Pavek P; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic. pavek@faf.cuni.cz. |
| Source: | Nature communications [Nat Commun] 2025 Feb 06; Vol. 16 (1), pp. 1418. Date of Electronic Publication: 2025 Feb 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-025-56642-y |
