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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.

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Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Authors: Dusek J; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Mejdrová I; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Dohnalová K; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; First Faculty of Medicine, Charles University, Prague, Czech Republic., Smutny T; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Chalupsky K; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Krutakova M; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Skoda J; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Rashidian A; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Tübingen, Germany., Pavkova I; Military Faculty of Medicine, University of Defence, Hradec Králové, Czech Republic., Škach K; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Hricová J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Chocholouskova M; Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic., Smutna L; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Kamaraj R; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Hroch M; Department of Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Leníček M; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic., Mičuda S; Institute of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Pijnenburg D; PamGene, 's-Hertogenbosch, The Netherlands., van Beuningen R; PamGene, 's-Hertogenbosch, The Netherlands., Holčapek M; Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic., Vítek L; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic.; 4th Department of Internal Medicine, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic., Ingelman-Sundberg M; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Burk O; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Tuebingen, Germany., Kronenberger T; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Nencka R; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic. radim.nencka@uochb.cas.cz., Pavek P; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic. pavek@faf.cuni.cz.
Source: Nature communications [Nat Commun] 2025 Feb 06; Vol. 16 (1), pp. 1418. Date of Electronic Publication: 2025 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
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  Data: <searchLink fieldCode="AU" term="%22Dusek+J%22">Dusek J</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Mejdrová+I%22">Mejdrová I</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Dohnalová+K%22">Dohnalová K</searchLink>; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Smutny+T%22">Smutny T</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Chalupsky+K%22">Chalupsky K</searchLink>; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Krutakova+M%22">Krutakova M</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Skoda+J%22">Skoda J</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Rashidian+A%22">Rashidian A</searchLink>; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pavkova+I%22">Pavkova I</searchLink>; Military Faculty of Medicine, University of Defence, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Škach+K%22">Škach K</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hricová+J%22">Hricová J</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Chocholouskova+M%22">Chocholouskova M</searchLink>; Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Smutna+L%22">Smutna L</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kamaraj+R%22">Kamaraj R</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hroch+M%22">Hroch M</searchLink>; Department of Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Leníček+M%22">Leníček M</searchLink>; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Mičuda+S%22">Mičuda S</searchLink>; Institute of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Pijnenburg+D%22">Pijnenburg D</searchLink>; PamGene, 's-Hertogenbosch, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Beuningen+R%22">van Beuningen R</searchLink>; PamGene, 's-Hertogenbosch, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Holčapek+M%22">Holčapek M</searchLink>; Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Vítek+L%22">Vítek L</searchLink>; Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic.; 4th Department of Internal Medicine, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Ingelman-Sundberg+M%22">Ingelman-Sundberg M</searchLink>; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Burk+O%22">Burk O</searchLink>; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kronenberger+T%22">Kronenberger T</searchLink>; Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Tübingen, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Nencka+R%22">Nencka R</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic. radim.nencka@uochb.cas.cz.<br /><searchLink fieldCode="AU" term="%22Pavek+P%22">Pavek P</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic. pavek@faf.cuni.cz.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Feb 06; Vol. 16 (1), pp. 1418. <i>Date of Electronic Publication: </i>2025 Feb 06.
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