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A validated single-step saliva and serum sample extraction LC-MS/MS method for the analysis of nicotine, cotinine and 3'-hydroxycotinine for clinical vaping studies.

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Title: A validated single-step saliva and serum sample extraction LC-MS/MS method for the analysis of nicotine, cotinine and 3'-hydroxycotinine for clinical vaping studies.
Authors: van der Velpen V; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Pharmacology, University of Bern, Switzerland., Liakoni E; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Hirt MB; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Pharmacology, University of Bern, Switzerland., Vonwyl CM; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Christen SE; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Switzerland., Duthaler U; Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland; Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland; Division of Clinical Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Jacob P; Clinical Pharmacology Program, Division of Cardiology, Department of Medicine, University of California, San Francisco, USA., Haschke M; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Pharmacology, University of Bern, Switzerland. Electronic address: manuel.haschke@insel.ch.
Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Jun 15; Vol. 258, pp. 116703. Date of Electronic Publication: 2025 Jan 27.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A validated single-step saliva and serum sample extraction LC-MS/MS method for the analysis of nicotine, cotinine and 3'-hydroxycotinine for clinical vaping studies.
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  Data: <searchLink fieldCode="AU" term="%22van+der+Velpen+V%22">van der Velpen V</searchLink>; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Pharmacology, University of Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liakoni+E%22">Liakoni E</searchLink>; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hirt+MB%22">Hirt MB</searchLink>; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Pharmacology, University of Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vonwyl+CM%22">Vonwyl CM</searchLink>; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Christen+SE%22">Christen SE</searchLink>; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Duthaler+U%22">Duthaler U</searchLink>; Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland; Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland; Division of Clinical Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jacob+P%22">Jacob P</searchLink>; Clinical Pharmacology Program, Division of Cardiology, Department of Medicine, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Haschke+M%22">Haschke M</searchLink>; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Pharmacology, University of Bern, Switzerland. Electronic address: manuel.haschke@insel.ch.
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  Data: <searchLink fieldCode="JN" term="%228309336%22">Journal of pharmaceutical and biomedical analysis</searchLink> [J Pharm Biomed Anal] 2025 Jun 15; Vol. 258, pp. 116703. <i>Date of Electronic Publication: </i>2025 Jan 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8309336 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-264X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207317085%22">07317085 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Biomed Anal <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jpba.2025.116703
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              Text: 2025 Jun 15
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