Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathways.
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| Title: | Molecular basis for the disease-modifying effects of belimumab in systemic lupus erythematosus and molecular predictors of early response: blood transcriptome analysis implicates the innate immunity and DNA damage response pathways. |
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| Authors: | Moysidou GS; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University Faculty of Medicine, Athens, Greece., Garantziotis P; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany., Sentis G; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Nikoleri D; Laboratory of Auoimmunity-Inflammation, Institute of Molecular Biology and Biotechnology, Heraklion, Greece., Malissovas N; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Nikoloudaki M; Rheumatology, Clinical Immunology and Allergy Department, University of Crete School of Medicine, Heraklion, Greece., Stergioti EM; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Polia S; Rheumatology, Clinical Immunology and Allergy Department, University of Crete School of Medicine, Heraklion, Greece., Paschalidis N; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Filia A; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece., Grigoriou M; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece; 1st Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace - Alexandropoulis Campus, Alexandroupolis, Greece., Nikolopoulos D; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece; Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Kapsala N; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University Faculty of Medicine, Athens, Greece., Katechis S; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University School of Medicine, Athens, Greece., Fanouriakis A; 4th Department of Medicine, National and Kapodistrian University Faculty of Medicine, Athens, Greece., Bertsias G; Rheumatology, Clinical Immunology and Allergy Department, University of Crete School of Medicine, Heraklion, Greece; Laboratory of Autoimmunity-Inflammation, Institute of Molecular Biology and Biotechnology, Heraklion, Greece. Electronic address: https://twitter.com/george_bertsias., Boumpas DT; Laboratory of Autoimmunity and Inflammation, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy, Athens, Greece; 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University Faculty of Medicine, Athens, Greece. Electronic address: boumpasd@uoc.gr. |
| Source: | Annals of the rheumatic diseases [Ann Rheum Dis] 2025 Feb; Vol. 84 (2), pp. 262-273. Date of Electronic Publication: 2025 Jan 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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