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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway.

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Title: Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway.
Authors: Park JH; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Jung KH; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Jia D; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA., Yang S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Attri KS; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Ahn S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Murthy D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Samanta T; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Dutta D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Ghidey M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Chatterjee S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Han SY; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Pedroza DA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Tiwari A; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Lee JV; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA., Davis C; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA., Li S; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA., Putluri V; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Creighton CJ; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Putluri N; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Dobrolecki LE; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Lewis MT; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Rosen JM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Onuchic JN; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA., Goga A; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA., Kaipparettu BA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: kaippare@bcm.edu.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Feb 18; Vol. 6 (2), pp. 101941. Date of Electronic Publication: 2025 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway.
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  Data: <searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Jung+KH%22">Jung KH</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Jia+D%22">Jia D</searchLink>; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Attri+KS%22">Attri KS</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ahn+S%22">Ahn S</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Murthy+D%22">Murthy D</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Samanta+T%22">Samanta T</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+D%22">Dutta D</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ghidey+M%22">Ghidey M</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+S%22">Chatterjee S</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Han+SY%22">Han SY</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Pedroza+DA%22">Pedroza DA</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+A%22">Tiwari A</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JV%22">Lee JV</searchLink>; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Davis+C%22">Davis C</searchLink>; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Putluri+V%22">Putluri V</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Creighton+CJ%22">Creighton CJ</searchLink>; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Putluri+N%22">Putluri N</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Dobrolecki+LE%22">Dobrolecki LE</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+MT%22">Lewis MT</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+JM%22">Rosen JM</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Onuchic+JN%22">Onuchic JN</searchLink>; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA.<br /><searchLink fieldCode="AU" term="%22Goga+A%22">Goga A</searchLink>; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Kaipparettu+BA%22">Kaipparettu BA</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: kaippare@bcm.edu.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2025 Feb 18; Vol. 6 (2), pp. 101941. <i>Date of Electronic Publication: </i>2025 Feb 10.
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