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Investigating DRD2 and HTR2A polymorphisms in treatment-resistant schizophrenia: a comparative analysis with other treatment-resistant mental disorders and the healthy state.

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Title: Investigating DRD2 and HTR2A polymorphisms in treatment-resistant schizophrenia: a comparative analysis with other treatment-resistant mental disorders and the healthy state.
Authors: Del Casale A; Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, Sapienza University of Rome, Center for Precision Medicine, Sant'Andrea University Hospital, 00189, Rome, Italy. antonio.delcasale@uniroma1.it., Gentile G; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., Lardani S; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., Modesti MN; Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, 00185, Rome, Italy.; Local Health Authority Rome 6, Mental Health Department, Mental Health Center - CSM Frascati, 00044, Frascati (RM), Italy., Arena JF; Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, Sapienza University of Rome, Center for Precision Medicine, Sant'Andrea University Hospital, 00189, Rome, Italy., Zocchi C; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., De Luca O; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., Parmigiani G; Department of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University of Rome, 00185, Rome, Italy., Angeletti G; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., Ferracuti S; Department of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University of Rome, 00185, Rome, Italy.; Unit of Risk Management, Sant'Andrea University Hospital, 00189, Rome, Italy., Preissner R; Structural Bioinformatics Group, Institute for Physiology, Charité-University Medicine Berlin, 10115, Berlin, Germany., Simmaco M; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., Borro M; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy., Pompili M; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.
Source: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2026 Apr; Vol. 276 (3), pp. 1221-1231. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9103030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8491 (Electronic) Linking ISSN: 09401334 NLM ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Investigating DRD2 and HTR2A polymorphisms in treatment-resistant schizophrenia: a comparative analysis with other treatment-resistant mental disorders and the healthy state.
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  Data: <searchLink fieldCode="AU" term="%22Del+Casale+A%22">Del Casale A</searchLink>; Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, Sapienza University of Rome, Center for Precision Medicine, Sant'Andrea University Hospital, 00189, Rome, Italy. antonio.delcasale@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Gentile+G%22">Gentile G</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lardani+S%22">Lardani S</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Modesti+MN%22">Modesti MN</searchLink>; Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, 00185, Rome, Italy.; Local Health Authority Rome 6, Mental Health Department, Mental Health Center - CSM Frascati, 00044, Frascati (RM), Italy.<br /><searchLink fieldCode="AU" term="%22Arena+JF%22">Arena JF</searchLink>; Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, Sapienza University of Rome, Center for Precision Medicine, Sant'Andrea University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zocchi+C%22">Zocchi C</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+O%22">De Luca O</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Parmigiani+G%22">Parmigiani G</searchLink>; Department of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Angeletti+G%22">Angeletti G</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ferracuti+S%22">Ferracuti S</searchLink>; Department of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University of Rome, 00185, Rome, Italy.; Unit of Risk Management, Sant'Andrea University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Preissner+R%22">Preissner R</searchLink>; Structural Bioinformatics Group, Institute for Physiology, Charité-University Medicine Berlin, 10115, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Simmaco+M%22">Simmaco M</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Borro+M%22">Borro M</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Laboratory and Advanced Molecular Diagnostics, Center for Precision Medicine, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pompili+M%22">Pompili M</searchLink>; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Unit of Psychiatry, 'Sant'Andrea' University Hospital, 00189, Rome, Italy.
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