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In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.

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Title: In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
Authors: De Giorgi M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Park SH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Castoreno A; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Cao M; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley A; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Saxena L; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Chuecos MA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA., Walkey CJ; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Doerfler AM; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Furgurson MN; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Ljungberg MC; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Patel KR; Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA., Hyde S; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Chickering T; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Lefebvre S; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Wassarman K; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Miller P; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Qin J; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Schlegel MK; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Zlatev I; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Han J; Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada.; UVic-GBC Proteomics Centre, Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 5C2, Canada., Beeton C; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Li RG; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Kim J; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Martin JF; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Bissig KD; Department of Pediatrics, Alice and Y. T. Chen Center for Genetics and Genomics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA., Jadhav V; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Feb 12; Vol. 17 (785), pp. eadk3920. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
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