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Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

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Title: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
Authors: Johnson EC; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Miller AP; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Hatoum AS; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Deak JD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Balbona JV; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Baranger DA; Department of Psychological and Brain Sciences, Washington University in St Louis, Saint Louis, MO, USA., Galimberti M; Department of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Sanichwankul K; Suanprung Psychiatric Hospital, Chiang Mai, Thailand., Thorgeirsson T; deCODE Genetics/Amgen, Sturlugata 8, IS-101, Reykjavik, Iceland., Colbert SM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Adhikari K; Department of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Docherty A; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA., Degenhardt L; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia., Edwards T; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Fox L; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Giannelis A; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Jeffries P; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Korhonen T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Morrison C; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Nunez YZ; Department of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Palviainen T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Su MH; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Villela PNR; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Wetherill L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Willoughby EA; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Zellers S; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Bierut L; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Buchwald J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Copeland W; Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA., Corley R; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Friedman NP; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Foroud TM; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Gillespie NA; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gizer IR; Department of Psychological Sciences, University of Missouri, Columbia, MO, USA., Heath AC; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Hickie IB; Brain and Mind Institute, University of Sydney, New South Wales, Sydney, Australia., Kaprio JA; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Keller MC; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Lee JL; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Lind PA; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Madden PA; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Maes HH; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McGue M; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.; School of Psychology, University of Queensland, Brisbane, Australia., Nelson EC; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA., Pearson JV; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Australia., Porjesz B; Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Health Science University, Brooklyn, NY, USA., Stallings M; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Vrieze S; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Wilhelmsen KC; Department of Neurology and Genetics and the Bowles Center of Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.; Renaissance Computing Institute, Chapel Hill, NC, USA., Walters RK; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Polimanti R; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), VA Connecticut Healthcare System, West Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA., Malison RT; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; The Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven, CT, USA., Zhou H; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Stefansson K; deCODE Genetics/Amgen, Sturlugata 8, IS-101, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, IS-101, Reykjavik, Iceland., Potenza MN; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.; Child Study Center, Yale School of Medicine, New Haven, CT, USA.; Connecticut Council on Problem Gambling, Wethersfield, CT, USA.; Connecticut Mental Health Center, New Haven, CT, USA., Mutirangura A; Department of Anatomy, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Shotelersuk V; Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand., Kalayasiri R; Department of Psychiatry, Epidemiology of Psychiatric Disorders and Mental Health Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Psychiatry, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Edenberg HJ; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Gelernter J; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA., Agrawal A; Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Feb 03. Date of Electronic Publication: 2025 Feb 03.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
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Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Kalayasiri+R%22">Kalayasiri R</searchLink>; Department of Psychiatry, Epidemiology of Psychiatric Disorders and Mental Health Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Psychiatry, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Edenberg+HJ%22">Edenberg HJ</searchLink>; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Gelernter+J%22">Gelernter J</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; 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            NameFull: Buchwald J
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            NameFull: Gizer IR
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            NameFull: Hickie IB
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            NameFull: Kaprio JA
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          Name:
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            NameFull: Malison RT
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          Name:
            NameFull: Stefansson K
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          Name:
            NameFull: Potenza MN
      – PersonEntity:
          Name:
            NameFull: Mutirangura A
      – PersonEntity:
          Name:
            NameFull: Shotelersuk V
      – PersonEntity:
          Name:
            NameFull: Kalayasiri R
      – PersonEntity:
          Name:
            NameFull: Edenberg HJ
      – PersonEntity:
          Name:
            NameFull: Gelernter J
      – PersonEntity:
          Name:
            NameFull: Agrawal A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 02
              Text: 2025 Feb 03
              Type: published
              Y: 2025
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
ResultId 1