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TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts.

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Title: TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts.
Authors: White SE; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Ten63 Therapeutics, Durham, NC, USA., Schwartze TA; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Mukundan A; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Schoenherr C; Cancer Research UK Scotland Institute, University of Glasgow, Glasgow, UK., Singh SP; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.; Department of Biological Sciences, Birla Institute of Technology and Science-Pilani, Pilani, Rajasthan, India., van Dinther M; Oncode Institute and Department of Cell and Chemical Biology, University of Leiden, Leiden, The Netherlands., Cunningham KT; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., White MPJ; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Campion T; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Pritchard J; Cancer Research UK Scotland Institute, University of Glasgow, Glasgow, UK., Hinck CS; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ten Dijke P; Oncode Institute and Department of Cell and Chemical Biology, University of Leiden, Leiden, The Netherlands., Inman GJ; Cancer Research UK Scotland Institute, University of Glasgow, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Maizels RM; Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Hinck AP; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ahinck@pitt.edu.
Source: Nature communications [Nat Commun] 2025 Feb 21; Vol. 16 (1), pp. 1847. Date of Electronic Publication: 2025 Feb 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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