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STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem/progenitor cells.

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Title: STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem/progenitor cells.
Authors: Huang J; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Xie J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute; Shanghai Key Laboratory for Cancer Systems Regulation and Clinical Translation; Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang Y; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Sheng M; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Sun Y; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Chen P; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Rong S; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Yin D; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Wang Y; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China., Zhu P; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510100, China.; Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou Key Laboratory of Cardiac Pathogenesis and Prevention, Guangzhou, China., Bohlander SK; Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand., Xu GL; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.; CAS Key Laboratory of Epigenetic Regulation and Intervention, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China., Gao H; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China. gaohai@fudan.edu.cn., Zhou D; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 201399, China. danzhou@fudan.edu.cn., Shi Y; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China. shiyuheng@fudan.edu.cn.; Huadong hospital, Fudan university, Shanghai, 200040, China. shiyuheng@fudan.edu.cn.
Source: Leukemia [Leukemia] 2025 Apr; Vol. 39 (4), pp. 929-941. Date of Electronic Publication: 2025 Feb 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem/progenitor cells.
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  Data: <searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute; Shanghai Key Laboratory for Cancer Systems Regulation and Clinical Translation; Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Sheng+M%22">Sheng M</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Rong+S%22">Rong S</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Yin+D%22">Yin D</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Zhu+P%22">Zhu P</searchLink>; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510100, China.; Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou Key Laboratory of Cardiac Pathogenesis and Prevention, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Bohlander+SK%22">Bohlander SK</searchLink>; Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Xu+GL%22">Xu GL</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.; CAS Key Laboratory of Epigenetic Regulation and Intervention, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China. gaohai@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+D%22">Zhou D</searchLink>; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 201399, China. danzhou@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China. shiyuheng@fudan.edu.cn.; Huadong hospital, Fudan university, Shanghai, 200040, China. shiyuheng@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2025 Apr; Vol. 39 (4), pp. 929-941. <i>Date of Electronic Publication: </i>2025 Feb 22.
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        Value: 10.1038/s41375-025-02542-5
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              Text: 2025 Apr
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