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MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.

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Title: MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.
Authors: Gao YP; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China., Lu JT; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China., Zhang HJ; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China., Cui ZM; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China., Guo Y; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China., Zhang X; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China., Wang W; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang, China., Wang XY; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, China., Wang TY; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, China., Jia YL; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.
Source: Biotechnology and bioengineering [Biotechnol Bioeng] 2025 Jun; Vol. 122 (6), pp. 1461-1471. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.
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  Data: <searchLink fieldCode="AU" term="%22Gao+YP%22">Gao YP</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Lu+JT%22">Lu JT</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HJ%22">Zhang HJ</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Cui+ZM%22">Cui ZM</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Qiu+LL%22">Qiu LL</searchLink>; School of Basic Medicine, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+XY%22">Wang XY</searchLink>; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Jia+YL%22">Jia YL</searchLink>; School of Pharmacy, XinXiang Medical University, Xinxiang, China.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, China.
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  Data: <searchLink fieldCode="JN" term="%227502021%22">Biotechnology and bioengineering</searchLink> [Biotechnol Bioeng] 2025 Jun; Vol. 122 (6), pp. 1461-1471. <i>Date of Electronic Publication: </i>2025 Feb 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7502021 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200063592%22">00063592 </searchLink><i>NLM ISO Abbreviation: </i>Biotechnol Bioeng <i>Subsets: </i>MEDLINE
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        Value: 10.1002/bit.28962
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        StartPage: 1461
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      – TitleFull: MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.
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            NameFull: Gao YP
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            – D: 01
              M: 06
              Text: 2025 Jun
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              Y: 2025
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              Value: 122
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