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Polygenic risk scores for eGFR are associated with age at kidney failure.

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Title: Polygenic risk scores for eGFR are associated with age at kidney failure.
Authors: Collins KE; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland.; SFI Centre for Research Training in Genomics Data Science, University of Galway, Galway, Ireland., Gilbert E; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland., Mauduit V; Nantes University, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France., Gaheer P; Division of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada., Elhassan EAE; Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Benson KA; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland., Osman SM; Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Hill C; Centre for Public Health, Queen's University Belfast, Belfast, UK., McKnight AJ; Centre for Public Health, Queen's University Belfast, Belfast, UK., Maxwell AP; Centre for Public Health, Queen's University Belfast, Belfast, UK., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., de Borst MH; Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Guan W; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Jacobson PA; Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA., Israni AK; University of Texas Medical Branch, Galveston, TX, USA., Keating BJ; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lord GM; School of Immunology and Microbial Sciences, University College London, London, UK., Markkinen S; Finnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland., Helanterä I; Helsinki University Hospital, Transplantation and Liver Surgery, Helsinki, Finland., Hyvärinen K; Finnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland., Partanen J; Finnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland., Madden SF; Data Science Centre, Beaux Lane House, Royal College of Surgeons in Ireland, Dublin, Ireland., Storrar J; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; University of Manchester, Manchester, UK., Sinha S; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; University of Manchester, Manchester, UK., Kalra PA; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; University of Manchester, Manchester, UK., Lanktree MB; Division of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada., Limou S; Nantes University, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France., Cavalleri GL; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland.; SFI Centre for Research Training in Genomics Data Science, University of Galway, Galway, Ireland., Conlon PJ; Division of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada. peterconlon@beaumont.ie.; Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland. peterconlon@beaumont.ie.
Source: Journal of nephrology [J Nephrol] 2025 Apr; Vol. 38 (3), pp. 969-978. Date of Electronic Publication: 2025 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Italy NLM ID: 9012268 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6059 (Electronic) Linking ISSN: 11218428 NLM ISO Abbreviation: J Nephrol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Polygenic risk scores for eGFR are associated with age at kidney failure.
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  Data: <searchLink fieldCode="AU" term="%22Collins+KE%22">Collins KE</searchLink>; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland.; SFI Centre for Research Training in Genomics Data Science, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Gilbert+E%22">Gilbert E</searchLink>; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Mauduit+V%22">Mauduit V</searchLink>; Nantes University, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Gaheer+P%22">Gaheer P</searchLink>; Division of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Elhassan+EAE%22">Elhassan EAE</searchLink>; Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Benson+KA%22">Benson KA</searchLink>; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Osman+SM%22">Osman SM</searchLink>; Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Hill+C%22">Hill C</searchLink>; Centre for Public Health, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McKnight+AJ%22">McKnight AJ</searchLink>; Centre for Public Health, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Maxwell+AP%22">Maxwell AP</searchLink>; Centre for Public Health, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Most+PJ%22">van der Most PJ</searchLink>; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Borst+MH%22">de Borst MH</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Guan+W%22">Guan W</searchLink>; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jacobson+PA%22">Jacobson PA</searchLink>; Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Israni+AK%22">Israni AK</searchLink>; University of Texas Medical Branch, Galveston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Keating+BJ%22">Keating BJ</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lord+GM%22">Lord GM</searchLink>; School of Immunology and Microbial Sciences, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Markkinen+S%22">Markkinen S</searchLink>; Finnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Helanterä+I%22">Helanterä I</searchLink>; Helsinki University Hospital, Transplantation and Liver Surgery, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Hyvärinen+K%22">Hyvärinen K</searchLink>; Finnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Partanen+J%22">Partanen J</searchLink>; Finnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Madden+SF%22">Madden SF</searchLink>; Data Science Centre, Beaux Lane House, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Storrar+J%22">Storrar J</searchLink>; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Sinha+S%22">Sinha S</searchLink>; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Kalra+PA%22">Kalra PA</searchLink>; Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Lanktree+MB%22">Lanktree MB</searchLink>; Division of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Limou+S%22">Limou S</searchLink>; Nantes University, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Cavalleri+GL%22">Cavalleri GL</searchLink>; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; The Science Foundation Ireland FutureNeuro Centre of Excellence, Dublin, Ireland.; SFI Centre for Research Training in Genomics Data Science, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Conlon+PJ%22">Conlon PJ</searchLink>; Division of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada. peterconlon@beaumont.ie.; Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland. peterconlon@beaumont.ie.
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