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Geographic and age-related variations in mutational processes in colorectal cancer.

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Title: Geographic and age-related variations in mutational processes in colorectal cancer.
Authors: Díaz-Gay M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Digital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Dos Santos W; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Moody S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Kazachkova M; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA., Abbasi A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Steele CD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Vangara R; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Senkin S; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Wang J; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Fitzgerald S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Bergstrom EN; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Khandekar A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Otlu B; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey., Abedi-Ardekani B; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., de Carvalho AC; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Cattiaux T; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Penha RCC; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Gaborieau V; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Chopard P; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Carreira C; Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Cheema S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Latimer C; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Teague JW; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Mukeriya A; Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Zaridze D; Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia., Cox R; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, ON, Canada., Albert M; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Centre for Biodiversity Genomics, University of Guelph, Guelph, ON, Canada., Phouthavongsy L; Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, ON, Canada., Gallinger S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Malekzadeh R; Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Niavarani A; Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Miladinov M; Clinic for Digestive Surgery - First Surgical Clinic, University Clinical Centre of Serbia, Belgrade, Serbia., Erić K; Department of Pathology, University Clinical Centre of Serbia, Belgrade, Serbia., Milosavljevic S; International Organization for Cancer Prevention and Research, Belgrade, Serbia., Sangrajrang S; National Cancer Institute, Bangkok, Thailand., Curado MP; Department of Epidemiology, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Aguiar S; Colon Cancer Reference Center, A.C. Camargo Cancer Center, Sao Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, Minho University, Braga, Portugal., Reis MT; Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil., Romagnolo LG; Department of Colorectal Oncology Surgery, Barretos Cancer Hospital, Barretos, Brazil., Guimarães DP; Department of Endoscopy, Barretos Cancer Hospital, Barretos, Brazil., Holcatova I; Institute of Public Health & Preventive Medicine, 2 Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Oncology, 2 Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic., Kalvach J; Surgery Department, 2 Faculty of Medicine, Charles University and Central Military Hospital, Prague, Czech Republic.; 2 Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.; Institute of Animal Physiology and Genetics Czech Academy of Science, Libechov, Czech Republic.; Clinical Center ISCARE, Prague, Czech Republic., Vaccaro CA; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)- CONICET- Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina., Piñero TA; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)- CONICET- Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina., Świątkowska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland., Lissowska J; The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland., Roszkowska-Purska K; Department of Pathology, The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland., Huertas-Salgado A; Oncological pathology group, Terry Fox National Tumor Bank (Banco Nacional de Tumores Terry Fox), National Cancer Institute, Bogotá, Colombia., Shibata T; Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan., Shiba S; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan., Sangkhathat S; Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand., Chitapanarux T; Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Roshandel G; Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran., Ashton-Prolla P; Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil., Damin DC; Department of Surgery, Division of Colorectal Surgery, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil., de Oliveira FH; Department of Pathology, Anatomic Pathology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil., Humphreys L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Lawley TD; Parasites and Microbes, Wellcome Sanger Institute, Cambridge, UK., Perdomo S; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK., Brennan P; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Alexandrov LB; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Feb 21. Date of Electronic Publication: 2025 Feb 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Geographic and age-related variations in mutational processes in colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Díaz-Gay+M%22">Díaz-Gay M</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Digital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+W%22">Dos Santos W</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Moody+S%22">Moody S</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kazachkova+M%22">Kazachkova M</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abbasi+A%22">Abbasi A</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Steele+CD%22">Steele CD</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vangara+R%22">Vangara R</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; 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Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Otlu+B%22">Otlu B</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Abedi-Ardekani+B%22">Abedi-Ardekani B</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22de+Carvalho+AC%22">de Carvalho AC</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Cattiaux+T%22">Cattiaux T</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Penha+RCC%22">Penha RCC</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Gaborieau+V%22">Gaborieau V</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Chopard+P%22">Chopard P</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Carreira+C%22">Carreira C</searchLink>; Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Cheema+S%22">Cheema S</searchLink>; 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Blokhin National Medical Research Centre of Oncology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Zaridze+D%22">Zaridze D</searchLink>; Clinical Epidemiology, N.N. 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Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan.<br /><searchLink fieldCode="AU" term="%22Sangkhathat+S%22">Sangkhathat S</searchLink>; Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.<br /><searchLink fieldCode="AU" term="%22Chitapanarux+T%22">Chitapanarux T</searchLink>; Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.<br /><searchLink fieldCode="AU" term="%22Roshandel+G%22">Roshandel G</searchLink>; Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.<br /><searchLink fieldCode="AU" term="%22Ashton-Prolla+P%22">Ashton-Prolla P</searchLink>; Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Damin+DC%22">Damin DC</searchLink>; Department of Surgery, Division of Colorectal Surgery, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+FH%22">de Oliveira FH</searchLink>; Department of Pathology, Anatomic Pathology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Humphreys+L%22">Humphreys L</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lawley+TD%22">Lawley TD</searchLink>; Parasites and Microbes, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Perdomo+S%22">Perdomo S</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+P%22">Brennan P</searchLink>; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.<br /><searchLink fieldCode="AU" term="%22Alexandrov+LB%22">Alexandrov LB</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, USA.
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          Name:
            NameFull: Teague JW
      – PersonEntity:
          Name:
            NameFull: Mukeriya A
      – PersonEntity:
          Name:
            NameFull: Zaridze D
      – PersonEntity:
          Name:
            NameFull: Cox R
      – PersonEntity:
          Name:
            NameFull: Albert M
      – PersonEntity:
          Name:
            NameFull: Phouthavongsy L
      – PersonEntity:
          Name:
            NameFull: Gallinger S
      – PersonEntity:
          Name:
            NameFull: Malekzadeh R
      – PersonEntity:
          Name:
            NameFull: Niavarani A
      – PersonEntity:
          Name:
            NameFull: Miladinov M
      – PersonEntity:
          Name:
            NameFull: Erić K
      – PersonEntity:
          Name:
            NameFull: Milosavljevic S
      – PersonEntity:
          Name:
            NameFull: Sangrajrang S
      – PersonEntity:
          Name:
            NameFull: Curado MP
      – PersonEntity:
          Name:
            NameFull: Aguiar S
      – PersonEntity:
          Name:
            NameFull: Reis RM
      – PersonEntity:
          Name:
            NameFull: Reis MT
      – PersonEntity:
          Name:
            NameFull: Romagnolo LG
      – PersonEntity:
          Name:
            NameFull: Guimarães DP
      – PersonEntity:
          Name:
            NameFull: Holcatova I
      – PersonEntity:
          Name:
            NameFull: Kalvach J
      – PersonEntity:
          Name:
            NameFull: Vaccaro CA
      – PersonEntity:
          Name:
            NameFull: Piñero TA
      – PersonEntity:
          Name:
            NameFull: Świątkowska B
      – PersonEntity:
          Name:
            NameFull: Lissowska J
      – PersonEntity:
          Name:
            NameFull: Roszkowska-Purska K
      – PersonEntity:
          Name:
            NameFull: Huertas-Salgado A
      – PersonEntity:
          Name:
            NameFull: Shibata T
      – PersonEntity:
          Name:
            NameFull: Shiba S
      – PersonEntity:
          Name:
            NameFull: Sangkhathat S
      – PersonEntity:
          Name:
            NameFull: Chitapanarux T
      – PersonEntity:
          Name:
            NameFull: Roshandel G
      – PersonEntity:
          Name:
            NameFull: Ashton-Prolla P
      – PersonEntity:
          Name:
            NameFull: Damin DC
      – PersonEntity:
          Name:
            NameFull: de Oliveira FH
      – PersonEntity:
          Name:
            NameFull: Humphreys L
      – PersonEntity:
          Name:
            NameFull: Lawley TD
      – PersonEntity:
          Name:
            NameFull: Perdomo S
      – PersonEntity:
          Name:
            NameFull: Stratton MR
      – PersonEntity:
          Name:
            NameFull: Brennan P
      – PersonEntity:
          Name:
            NameFull: Alexandrov LB
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 02
              Text: 2025 Feb 21
              Type: published
              Y: 2025
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
ResultId 1