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Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.

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Title: Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.
Authors: Seagle HM; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Joseph Maxwell Cleland Atlanta VA Medical Center, Atlanta, Georgia, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Akerele AT; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; School of Graduate Studies and Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee, United States of America.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., DeCorte JA; Vanderbilt Medical Scientist Training Program, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.; Department of Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, United States of America., Hellwege JN; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; VA Tennessee Valley Healthcare System (626), Nashville, Tennessee, United States of America., Breeyear JH; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America., Kim J; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Vanderbilt Medical Scientist Training Program, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Levin M; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Phoenix VA Health Care System; University of Arizona, Phoenix, Arizona, United States of., Khodurksy S; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Phoenix VA Health Care System; University of Arizona, Phoenix, Arizona, United States of., Bress A; Salt Lake City VA Medical Center, Salt Lake City, Utah, United States of America.; University of Utah, School of Medicine, Salt Lake City, Utah, United States of America., Lee K; Salt Lake City VA Medical Center, Salt Lake City, Utah, United States of America., Meiler J; Department of Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Germany., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Lee JS; Stanford University, Stanford, California, United States of America.; Palo Alto VA Medical Center, Palo Alto, California, United States of America., Heberer K; Palo Alto VA Medical Center, Palo Alto, California, United States of America., Miller DR; VA Center for Medication Safety, Department of Veterans Affairs, Chicago, Illinois, United States of America.; Center for Population Health, Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA, United States of America., Reaven P; Phoenix VA Health Care System; University of Arizona, Phoenix, Arizona, United States of., Chang KM; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Corporal Michael J. Crescenz Philadelphia VA Medical Center, Philadelphia, Pennsylvania, United States of America., Lynch JA; Salt Lake City VA Medical Center, Salt Lake City, Utah, United States of America.; University of Utah, School of Medicine, Salt Lake City, Utah, United States of America., Khankari NK; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Shuey MM; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; VA Tennessee Valley Healthcare System (626), Nashville, Tennessee, United States of America., Vujkovic M; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Corporal Michael J. Crescenz Philadelphia VA Medical Center, Philadelphia, Pennsylvania, United States of America.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Feb 21. Date of Electronic Publication: 2025 Feb 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.
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  Data: <searchLink fieldCode="AU" term="%22Seagle+HM%22">Seagle HM</searchLink>; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Joseph Maxwell Cleland Atlanta VA Medical Center, Atlanta, Georgia, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Akerele+AT%22">Akerele AT</searchLink>; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; School of Graduate Studies and Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee, United States of America.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22DeCorte+JA%22">DeCorte JA</searchLink>; Vanderbilt Medical Scientist Training Program, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.; Department of Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Hellwege+JN%22">Hellwege JN</searchLink>; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; VA Tennessee Valley Healthcare System (626), Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Breeyear+JH%22">Breeyear JH</searchLink>; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Vanderbilt Medical Scientist Training Program, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Levin+M%22">Levin M</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Phoenix VA Health Care System; University of Arizona, Phoenix, Arizona, United States of.<br /><searchLink fieldCode="AU" term="%22Khodurksy+S%22">Khodurksy S</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Phoenix VA Health Care System; University of Arizona, Phoenix, Arizona, United States of.<br /><searchLink fieldCode="AU" term="%22Bress+A%22">Bress A</searchLink>; Salt Lake City VA Medical Center, Salt Lake City, Utah, United States of America.; University of Utah, School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Salt Lake City VA Medical Center, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Meiler+J%22">Meiler J</searchLink>; Department of Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Gill+D%22">Gill D</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lee+JS%22">Lee JS</searchLink>; Stanford University, Stanford, California, United States of America.; Palo Alto VA Medical Center, Palo Alto, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Heberer+K%22">Heberer K</searchLink>; Palo Alto VA Medical Center, Palo Alto, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Miller+DR%22">Miller DR</searchLink>; VA Center for Medication Safety, Department of Veterans Affairs, Chicago, Illinois, United States of America.; Center for Population Health, Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA, United States of America.<br /><searchLink fieldCode="AU" term="%22Reaven+P%22">Reaven P</searchLink>; Phoenix VA Health Care System; University of Arizona, Phoenix, Arizona, United States of.<br /><searchLink fieldCode="AU" term="%22Chang+KM%22">Chang KM</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Corporal Michael J. Crescenz Philadelphia VA Medical Center, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Lynch+JA%22">Lynch JA</searchLink>; Salt Lake City VA Medical Center, Salt Lake City, Utah, United States of America.; University of Utah, School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Khankari+NK%22">Khankari NK</searchLink>; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Shuey+MM%22">Shuey MM</searchLink>; Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Edwards+TL%22">Edwards TL</searchLink>; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; VA Tennessee Valley Healthcare System (626), Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Vujkovic+M%22">Vujkovic M</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.; Corporal Michael J. Crescenz Philadelphia VA Medical Center, Philadelphia, Pennsylvania, United States of America.
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