Reduced removal of waste products from energy metabolism takes center stage in human brain aging.

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Title: Reduced removal of waste products from energy metabolism takes center stage in human brain aging.
Authors: Mangia S; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. mangia@umn.edu., DiNuzzo M; Netabolics SRL, Rome, RM, Italy., Ponticorvo S; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA., Dienel GA; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM, USA., Behar KL; Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA., Benveniste H; Department of Anesthesiology, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Hyder F; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA., Giove F; Centro Ricerche Enrico Fermi, Rome, RM, Italy.; Fondazione Santa Lucia IRCCS, Rome, RM, Italy., Herculano-Houzel S; Department of Psychology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Petroff OA; Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA., Eberly LE; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Filip P; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.; Department of Neurology, First Faculty of Medicine and General University Hospital, 121 08, Prague, Czech Republic., Michaeli S; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA., Rothman DL; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.
Source: Scientific reports [Sci Rep] 2025 Mar 08; Vol. 15 (1), pp. 8127. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mangia+S%22">Mangia S</searchLink>; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. mangia@umn.edu.<br /><searchLink fieldCode="AU" term="%22DiNuzzo+M%22">DiNuzzo M</searchLink>; Netabolics SRL, Rome, RM, Italy.<br /><searchLink fieldCode="AU" term="%22Ponticorvo+S%22">Ponticorvo S</searchLink>; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dienel+GA%22">Dienel GA</searchLink>; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM, USA.<br /><searchLink fieldCode="AU" term="%22Behar+KL%22">Behar KL</searchLink>; Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Benveniste+H%22">Benveniste H</searchLink>; Department of Anesthesiology, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hyder+F%22">Hyder F</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Giove+F%22">Giove F</searchLink>; Centro Ricerche Enrico Fermi, Rome, RM, Italy.; Fondazione Santa Lucia IRCCS, Rome, RM, Italy.<br /><searchLink fieldCode="AU" term="%22Herculano-Houzel+S%22">Herculano-Houzel S</searchLink>; Department of Psychology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Petroff+OA%22">Petroff OA</searchLink>; Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Eberly+LE%22">Eberly LE</searchLink>; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Filip+P%22">Filip P</searchLink>; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.; Department of Neurology, First Faculty of Medicine and General University Hospital, 121 08, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Michaeli+S%22">Michaeli S</searchLink>; Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Rothman+DL%22">Rothman DL</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.
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