Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders.

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Title: Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders.
Authors: Zhou Z; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA., Luquette LJ; Department of Biomedical Informatics, Harvard Medical School; Boston, MA, USA., Dong G; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Bioinformatics and Integrative Genomics Program, Harvard Medical School; Boston, MA, USA., Kim J; Department of Biological Sciences, Sungkyunkwan University; Suwon, South Korea., Ku J; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA., Kim K; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA., Bae M; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA., Shao DD; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Department of Neurology, Boston Children's Hospital; Boston, MA, USA., Sahile B; Program in Neuroscience, Harvard Medical School; Boston, MA, USA., Miller MB; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA., Huang AY; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School; Boston, MA, USA., Lagier-Tourenne C; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA., Lee EA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA., Walsh CA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA.; Howard Hughes Medical Institute; Boston, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 08. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Luquette+LJ%22">Luquette LJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dong+G%22">Dong G</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Bioinformatics and Integrative Genomics Program, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Biological Sciences, Sungkyunkwan University; Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Ku+J%22">Ku J</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bae+M%22">Bae M</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shao+DD%22">Shao DD</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Department of Neurology, Boston Children's Hospital; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sahile+B%22">Sahile B</searchLink>; Program in Neuroscience, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+MB%22">Miller MB</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+AY%22">Huang AY</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nathan+WJ%22">Nathan WJ</searchLink>; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nussenzweig+A%22">Nussenzweig A</searchLink>; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Park+PJ%22">Park PJ</searchLink>; Department of Biomedical Informatics, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lagier-Tourenne+C%22">Lagier-Tourenne C</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+EA%22">Lee EA</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+CA%22">Walsh CA</searchLink>; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.; Department of Pediatrics, Harvard Medical School; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA.; Howard Hughes Medical Institute; Boston, MA, USA.
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      – Type: doi
        Value: 10.1101/2025.03.03.641186
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      – Code: eng
        Text: English
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      – TitleFull: Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders.
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              Text: 2025 Mar 08
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