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3-Monothiopomalidomide, a new immunomodulatory imide drug (IMiD), blunts inflammation and mitigates ischemic stroke in the rat.

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Title: 3-Monothiopomalidomide, a new immunomodulatory imide drug (IMiD), blunts inflammation and mitigates ischemic stroke in the rat.
Authors: Chen KY; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.; Neuroscience Research Center, Taipei Medical University, Taipei, 110, Taiwan., Hsueh SC; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Parekh P; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Batsaikhan B; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Tweedie D; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Luo W; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Patel C; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA., Chiang YH; Neuroscience Research Center, Taipei Medical University, Taipei, 110, Taiwan.; Department of Neurosurgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan., Bambakidis N; Department of Neurosurgery, University Hospitals of Cleveland, Cleveland, OH, 44106, USA., Hoffer BJ; Department of Neurosurgery, University Hospitals of Cleveland, Cleveland, OH, 44106, USA., Huang CZ; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan., Yu SJ; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan., Wu KJ; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan., Wang Y; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan., Hong E; Aevis Bio Inc, Daejeon, 34141, Republic of Korea., Kim DS; Aevis Bio Inc, Daejeon, 34141, Republic of Korea. dskim@aevisbio.com.; Aevisbio Inc, Gaithersburg, MD, 20878, USA. dskim@aevisbio.com., Greig NH; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA. Greign@grc.nia.nih.gov.
Source: GeroScience [Geroscience] 2025 Aug; Vol. 47 (4), pp. 5763-5783. Date of Electronic Publication: 2025 Mar 17.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 3-Monothiopomalidomide, a new immunomodulatory imide drug (IMiD), blunts inflammation and mitigates ischemic stroke in the rat.
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  Data: <searchLink fieldCode="AU" term="%22Chen+KY%22">Chen KY</searchLink>; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.; Neuroscience Research Center, Taipei Medical University, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsueh+SC%22">Hsueh SC</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA.<br /><searchLink fieldCode="AU" term="%22Parekh+P%22">Parekh P</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA.<br /><searchLink fieldCode="AU" term="%22Batsaikhan+B%22">Batsaikhan B</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA.<br /><searchLink fieldCode="AU" term="%22Tweedie+D%22">Tweedie D</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA.<br /><searchLink fieldCode="AU" term="%22Luo+W%22">Luo W</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA.<br /><searchLink fieldCode="AU" term="%22Patel+C%22">Patel C</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA.<br /><searchLink fieldCode="AU" term="%22Chiang+YH%22">Chiang YH</searchLink>; Neuroscience Research Center, Taipei Medical University, Taipei, 110, Taiwan.; Department of Neurosurgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bambakidis+N%22">Bambakidis N</searchLink>; Department of Neurosurgery, University Hospitals of Cleveland, Cleveland, OH, 44106, USA.<br /><searchLink fieldCode="AU" term="%22Hoffer+BJ%22">Hoffer BJ</searchLink>; Department of Neurosurgery, University Hospitals of Cleveland, Cleveland, OH, 44106, USA.<br /><searchLink fieldCode="AU" term="%22Huang+CZ%22">Huang CZ</searchLink>; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+SJ%22">Yu SJ</searchLink>; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+KJ%22">Wu KJ</searchLink>; School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+E%22">Hong E</searchLink>; Aevis Bio Inc, Daejeon, 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+DS%22">Kim DS</searchLink>; Aevis Bio Inc, Daejeon, 34141, Republic of Korea. dskim@aevisbio.com.; Aevisbio Inc, Gaithersburg, MD, 20878, USA. dskim@aevisbio.com.<br /><searchLink fieldCode="AU" term="%22Greig+NH%22">Greig NH</searchLink>; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, MD, 21224, USA. Greign@grc.nia.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2025 Aug; Vol. 47 (4), pp. 5763-5783. <i>Date of Electronic Publication: </i>2025 Mar 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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