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Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles.

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Title: Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles.
Authors: Flynn A; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Pattison AD; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Balachander S; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Boehm E; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Bowen B; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Dwight T; Kolling Institute of Medical Research, Royal North Shore Hospital St Leonards NSW, Melbourne, Australia., Rossello FJ; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, 3052, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, VIC, 3052, Australia.; Australian Regenerative Medicine Institute, Monash University, Victoria, Australia., Hofmann O; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Martelotto L; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Zethoven M; Peter MacCallum Cancer Centre, Melbourne, Australia., Kirschner LS; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA., Else T; University of Michigan, Ann Arbor, MI, USA., Fishbein L; Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, University of Colorado, Aurora, CO, USA., Gill AJ; Sydney Medical School, University of Sydney, Sydney, NSW, Australia.; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards NSW, Sydney, Australia., Tischler AS; Tufts Medical Center, Boston, MA, USA., Giordano T; University of Michigan, Ann Arbor, MI, USA., Prodanov T; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Noble JR; Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Reddel RR; Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Trainer AH; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Ghayee HK; University of Florida and Malcom Randall VA Medical Center, Gainesville, FL, USA., Bourdeau I; Division of endocrinology and Research Center, Center hospitalier de l'Université de Montréal, Montreal, Canada., Elston M; Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand., Ishak D; Cancer Genetics Service, National Cancer Center Singapore, Singapore, Singapore., Ngeow Yuen Yie J; Cancer Genetics Service, National Cancer Center Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Hicks RJ; St Vincent's Dept of Medicine, University of Melbourne, Melbourne, VIC, Australia., Crona J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Åkerström T; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Stålberg P; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Dahia P; Div. Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, USA., Grimmond S; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia., Clifton-Bligh R; Kolling Institute of Medical Research, Royal North Shore Hospital St Leonards NSW, Melbourne, Australia. roderick.cliftonbligh@sydney.edu.au.; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. roderick.cliftonbligh@sydney.edu.au., Pacak K; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. karel@mail.nih.gov., Tothill RW; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia. rtothill@unimelb.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.
Source: Nature communications [Nat Commun] 2025 Mar 17; Vol. 16 (1), pp. 2632. Date of Electronic Publication: 2025 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles.
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  Data: <searchLink fieldCode="AU" term="%22Flynn+A%22">Flynn A</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pattison+AD%22">Pattison AD</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Balachander+S%22">Balachander S</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Boehm+E%22">Boehm E</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bowen+B%22">Bowen B</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dwight+T%22">Dwight T</searchLink>; 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Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Stålberg+P%22">Stålberg P</searchLink>; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Dahia+P%22">Dahia P</searchLink>; Div. Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Grimmond+S%22">Grimmond S</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Clifton-Bligh+R%22">Clifton-Bligh R</searchLink>; Kolling Institute of Medical Research, Royal North Shore Hospital St Leonards NSW, Melbourne, Australia. roderick.cliftonbligh@sydney.edu.au.; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. roderick.cliftonbligh@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22Pacak+K%22">Pacak K</searchLink>; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. karel@mail.nih.gov.<br /><searchLink fieldCode="AU" term="%22Tothill+RW%22">Tothill RW</searchLink>; Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, VIC, Australia. rtothill@unimelb.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. rtothill@unimelb.edu.au.
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