View in EDS

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.

Saved in:
Bibliographic Details
Title: Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.
Authors: Giroud M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Kuhn B; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Steiner S; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Westwood P; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Mendel M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Mani A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Pinard E; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Haap W; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Grether U; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Caramenti P; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Rombach D; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Zambaldo C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Ritter M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Schmid P; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Gasser C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Aregger N; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Séchet N; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Topp A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Bilyard M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Malnight-Alvarez A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Plitzko I; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Hilbert M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Kalayil S; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Burger D; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Bonardi C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Saal W; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Haider A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Wittwer MB; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Brigo A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Benz J; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Keaney J; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Mar 27; Vol. 68 (6), pp. 6558-6575. Date of Electronic Publication: 2025 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40100796
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Giroud+M%22">Giroud M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kuhn+B%22">Kuhn B</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Steiner+S%22">Steiner S</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Westwood+P%22">Westwood P</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mendel+M%22">Mendel M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mani+A%22">Mani A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pinard+E%22">Pinard E</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Haap+W%22">Haap W</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grether+U%22">Grether U</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Caramenti+P%22">Caramenti P</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rombach+D%22">Rombach D</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zambaldo+C%22">Zambaldo C</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ritter+M%22">Ritter M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schmid+P%22">Schmid P</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gasser+C%22">Gasser C</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aregger+N%22">Aregger N</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Séchet+N%22">Séchet N</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Topp+A%22">Topp A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bilyard+M%22">Bilyard M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Malnight-Alvarez+A%22">Malnight-Alvarez A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Plitzko+I%22">Plitzko I</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hilbert+M%22">Hilbert M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kalayil+S%22">Kalayil S</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Burger+D%22">Burger D</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonardi+C%22">Bonardi C</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Saal+W%22">Saal W</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Haider+A%22">Haider A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wittwer+MB%22">Wittwer MB</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brigo+A%22">Brigo A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Benz+J%22">Benz J</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Keaney+J%22">Keaney J</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Mar 27; Vol. 68 (6), pp. 6558-6575. <i>Date of Electronic Publication: </i>2025 Mar 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40100796
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.4c03127
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 6558
    Titles:
      – TitleFull: Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Giroud M
      – PersonEntity:
          Name:
            NameFull: Kuhn B
      – PersonEntity:
          Name:
            NameFull: Steiner S
      – PersonEntity:
          Name:
            NameFull: Westwood P
      – PersonEntity:
          Name:
            NameFull: Mendel M
      – PersonEntity:
          Name:
            NameFull: Mani A
      – PersonEntity:
          Name:
            NameFull: Pinard E
      – PersonEntity:
          Name:
            NameFull: Haap W
      – PersonEntity:
          Name:
            NameFull: Grether U
      – PersonEntity:
          Name:
            NameFull: Caramenti P
      – PersonEntity:
          Name:
            NameFull: Rombach D
      – PersonEntity:
          Name:
            NameFull: Zambaldo C
      – PersonEntity:
          Name:
            NameFull: Ritter M
      – PersonEntity:
          Name:
            NameFull: Schmid P
      – PersonEntity:
          Name:
            NameFull: Gasser C
      – PersonEntity:
          Name:
            NameFull: Aregger N
      – PersonEntity:
          Name:
            NameFull: Séchet N
      – PersonEntity:
          Name:
            NameFull: Topp A
      – PersonEntity:
          Name:
            NameFull: Bilyard M
      – PersonEntity:
          Name:
            NameFull: Malnight-Alvarez A
      – PersonEntity:
          Name:
            NameFull: Plitzko I
      – PersonEntity:
          Name:
            NameFull: Hilbert M
      – PersonEntity:
          Name:
            NameFull: Kalayil S
      – PersonEntity:
          Name:
            NameFull: Burger D
      – PersonEntity:
          Name:
            NameFull: Bonardi C
      – PersonEntity:
          Name:
            NameFull: Saal W
      – PersonEntity:
          Name:
            NameFull: Haider A
      – PersonEntity:
          Name:
            NameFull: Wittwer MB
      – PersonEntity:
          Name:
            NameFull: Brigo A
      – PersonEntity:
          Name:
            NameFull: Benz J
      – PersonEntity:
          Name:
            NameFull: Keaney J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 27
              M: 03
              Text: 2025 Mar 27
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 68
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1