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Discovery of ATP competitive PDHK1/2 dual inhibitors.

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Title: Discovery of ATP competitive PDHK1/2 dual inhibitors.
Authors: Xu H; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Ding D; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Han X; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Miao K; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Liang C; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Yun H; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Zhu W; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Dey F; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Zhao D; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Wu Y; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Reutlinger M; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Yang J; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Zhai G; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Lin Z; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Li C; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Wu W; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Xu B; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Han L; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Chen S; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Huang X; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Casagrande F; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Hilbert M; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Strebel Q; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Wichert M; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Westwood P; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Schäfer R; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Roth D; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Heer D; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Tian X; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Ma T; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Zhang T; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Zhao J; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Urich E; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Xia G; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Lassen K; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Shen HC; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China., Zou G; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China. Electronic address: ge.zou@roche.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Jul 01; Vol. 122, pp. 130190. Date of Electronic Publication: 2025 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Discovery of ATP competitive PDHK1/2 dual inhibitors.
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Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hilbert+M%22">Hilbert M</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Strebel+Q%22">Strebel Q</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wichert+M%22">Wichert M</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Westwood+P%22">Westwood P</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schäfer+R%22">Schäfer R</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roth+D%22">Roth D</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Heer+D%22">Heer D</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Ma+T%22">Ma T</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Urich+E%22">Urich E</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Xia+G%22">Xia G</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Lassen+K%22">Lassen K</searchLink>; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shen+HC%22">Shen HC</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Zou+G%22">Zou G</searchLink>; China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China. Electronic address: ge.zou@roche.com.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2025 Jul 01; Vol. 122, pp. 130190. <i>Date of Electronic Publication: </i>2025 Mar 17.
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