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DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients' airway epithelial cells.

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Title: DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients' airway epithelial cells.
Authors: Messingschlager M; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.; Freie Universität Berlin, Institute of Biology, Berlin, Germany., Mackowiak SD; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Voelker MT; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany., Bieg M; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Loske J; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.; Freie Universität Berlin, Institute of Biology, Berlin, Germany., Chua RL; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Liebig J; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Lukassen S; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Thürmann L; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany., Seegebarth A; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany., Twardziok S; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Doncevic D; Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany., Herrmann C; Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany., Lorenz S; Max Planck Institute for Molecular Genetics, Berlin, Germany., Klages S; Max Planck Institute for Molecular Genetics, Berlin, Germany., Steinbeis F; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Witzenrath M; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany., Kurth F; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Conrad C; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Sander LE; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany., Ishaque N; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany., Eils R; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.; Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany.; German Center for Lung Research (DZL), Giessen, Germany.; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany., Lehmann I; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany., Laudi S; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany., Trump S; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany. saskia.trump@bih-charite.de.
Source: EMBO molecular medicine [EMBO Mol Med] 2025 May; Vol. 17 (5), pp. 923-937. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients' airway epithelial cells.
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  Data: <searchLink fieldCode="AU" term="%22Messingschlager+M%22">Messingschlager M</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.; Freie Universität Berlin, Institute of Biology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mackowiak+SD%22">Mackowiak SD</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Voelker+MT%22">Voelker MT</searchLink>; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Bieg+M%22">Bieg M</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Loske+J%22">Loske J</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.; Freie Universität Berlin, Institute of Biology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Chua+RL%22">Chua RL</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Liebig+J%22">Liebig J</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lukassen+S%22">Lukassen S</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Thürmann+L%22">Thürmann L</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Seegebarth+A%22">Seegebarth A</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Twardziok+S%22">Twardziok S</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Doncevic+D%22">Doncevic D</searchLink>; Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Herrmann+C%22">Herrmann C</searchLink>; Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenz+S%22">Lorenz S</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Klages+S%22">Klages S</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbeis+F%22">Steinbeis F</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Witzenrath+M%22">Witzenrath M</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Kurth+F%22">Kurth F</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Conrad+C%22">Conrad C</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sander+LE%22">Sander LE</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Ishaque+N%22">Ishaque N</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Eils+R%22">Eils R</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.; Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany.; German Center for Lung Research (DZL), Giessen, Germany.; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+I%22">Lehmann I</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Laudi+S%22">Laudi S</searchLink>; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Trump+S%22">Trump S</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany. saskia.trump@bih-charite.de.
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