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6,7-Dimethoxy-2-methyl-4-substituted quinazolines: Design, synthesis, EGFR inhibitory activity, in vitro cytotoxicity, and in silico studies.

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Title: 6,7-Dimethoxy-2-methyl-4-substituted quinazolines: Design, synthesis, EGFR inhibitory activity, in vitro cytotoxicity, and in silico studies.
Authors: Saleh NS; Egyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St., Giza, 35521, Egypt., El-Sayed NNE; Egyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St., Giza, 35521, Egypt., Saleh OA; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical Industries Research Institute, National Research Centre, Egypt., Allam HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt., Mohamed NM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Modern University for Technology and Information MTI, Cairo, Egypt., Abbas SE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt., Said MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt. Electronic address: mona.abdelnoor@pharma.cu.edu.eg.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Jun 05; Vol. 290, pp. 117502. Date of Electronic Publication: 2025 Mar 15.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 6,7-Dimethoxy-2-methyl-4-substituted quinazolines: Design, synthesis, EGFR inhibitory activity, in vitro cytotoxicity, and in silico studies.
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  Data: <searchLink fieldCode="AU" term="%22Saleh+NS%22">Saleh NS</searchLink>; Egyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St., Giza, 35521, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+NNE%22">El-Sayed NNE</searchLink>; Egyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St., Giza, 35521, Egypt.<br /><searchLink fieldCode="AU" term="%22Saleh+OA%22">Saleh OA</searchLink>; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical Industries Research Institute, National Research Centre, Egypt.<br /><searchLink fieldCode="AU" term="%22Allam+HA%22">Allam HA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+NM%22">Mohamed NM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Modern University for Technology and Information MTI, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Abbas+SE%22">Abbas SE</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Said+MF%22">Said MF</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt. Electronic address: mona.abdelnoor@pharma.cu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2025 Jun 05; Vol. 290, pp. 117502. <i>Date of Electronic Publication: </i>2025 Mar 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun 05
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