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Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.

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Title: Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.
Authors: Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: batemanr@wustl.edu., Li Y; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: yanli833@wustl.edu., McDade EM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Llibre-Guerra JJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Clifford DB; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Atri A; Banner Sun Health Research Institute, Banner Health, Phoenix, AZ, USA., Mills SL; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Santacruz AM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Wang G; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Supnet C; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Benzinger TLS; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Gordon BA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Ibanez L; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Klein G; F Hoffmann-La Roche Ltd, Basel, Switzerland., Baudler M; F Hoffmann-La Roche Ltd, Basel, Switzerland., Doody RS; F Hoffmann-La Roche Ltd, Basel, Switzerland., Delmar P; F Hoffmann-La Roche Ltd, Basel, Switzerland., Kerchner GA; F Hoffmann-La Roche Ltd, Basel, Switzerland., Bittner T; F Hoffmann-La Roche Ltd, Basel, Switzerland., Wojtowicz J; F Hoffmann-La Roche Ltd, Basel, Switzerland., Bonni A; F Hoffmann-La Roche Ltd, Basel, Switzerland., Fontoura P; F Hoffmann-La Roche Ltd, Basel, Switzerland., Hofmann C; F Hoffmann-La Roche Ltd, Basel, Switzerland., Kulic L; F Hoffmann-La Roche Ltd, Basel, Switzerland., Hassenstab J; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Aschenbrenner AJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Perrin RJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Cruchaga C; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Renton AE; Department of Neuroscience, Icahn School of Medicine Mt Sinai, New York, NY, USA., Xiong C; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Goate AA; Department of Genetics and Genomic Sciences, Icahn School of Medicine Mt Sinai, New York, NY, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Snider BJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Mummery C; Department of Neurology, University College London, London, UK., Brooks WS; Neuroscience Research Australia, Sydney, NSW, Australia., Wallon D; Centre Hospitalier Universitaire de Rouen, Rouen, France., Berman SB; University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Roberson E; University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA., Masters CL; University of Melbourne, Melbourne, VIC, Australia., Galasko DR; Department of Neurosciences, University of California San Diego, San Diego, CA, USA., Jayadev S; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA., Sanchez-Valle R; Neurology Service, Hospital Clínic i Provincial de Barcelona, August Pi i Sunyer Biomedical Research Institute-Universitat de Barcelona, Barcelona, Spain., Pariente J; Department of Cognitive Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Kinsella J; Department of Neurology, St Vincent's University Hospital, Dublin, Ireland., van Dyck CH; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Gauthier S; Department of Neurology and Neurosurgery, McGill Center for Studies in Aging, McGill University, Montreal, QC, Canada., Hsiung GR; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Masellis M; Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Dubois B; Neurological Institute, Salpetriere University Hospital, Paris, France., Honig LS; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Jack CR; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Daniels A; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Aguillón D; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Allegri R; Department of Cognitive Neurology, Neuropsychiatry and Neuropsychology, Instituto de Investigaciones Neurologicas Raul Carrea (Fleni), Buenos Aires, Argentina., Chhatwal J; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Day G; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Fox NC; Department of Neurology, University College London, London, UK., Huey E; Department of Psychiatry and Human Behavior, Butler Hospital, Providence, RI, USA., Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Jucker M; Department Cellular Neurology, German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany., Lee JH; Department of Neurology, Asan Medical Center, Seoul, South Korea., Levey AI; Department of Pharmacology, Emory University, Atlanta, GA, USA., Levin J; Department of Neurology, Ludwig-Maximilians-University, Munich, Germany., Lopera F; Medicine School, Universidad de Antioquia, Medellín, Colombia., Roh J; Department of Neurology, Korea University Anam Hospital, Seoul, South Korea., Rosa-Neto P; Department of Neurology and Neurosurgery, McGill Center for Studies in Aging, McGill University, Montreal, QC, Canada., Schofield PR; Neuroscience Research Australia, Sydney, NSW, Australia.
Corporate Authors: Dominantly Inherited Alzheimer's Disease–Trials Unit
Source: The Lancet. Neurology [Lancet Neurol] 2025 Apr; Vol. 24 (4), pp. 316-330.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Clinical Trial, Phase II
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.
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            NameFull: Masellis M
      – PersonEntity:
          Name:
            NameFull: Dubois B
      – PersonEntity:
          Name:
            NameFull: Honig LS
      – PersonEntity:
          Name:
            NameFull: Jack CR
      – PersonEntity:
          Name:
            NameFull: Daniels A
      – PersonEntity:
          Name:
            NameFull: Aguillón D
      – PersonEntity:
          Name:
            NameFull: Allegri R
      – PersonEntity:
          Name:
            NameFull: Chhatwal J
      – PersonEntity:
          Name:
            NameFull: Day G
      – PersonEntity:
          Name:
            NameFull: Fox NC
      – PersonEntity:
          Name:
            NameFull: Huey E
      – PersonEntity:
          Name:
            NameFull: Ikeuchi T
      – PersonEntity:
          Name:
            NameFull: Jucker M
      – PersonEntity:
          Name:
            NameFull: Lee JH
      – PersonEntity:
          Name:
            NameFull: Levey AI
      – PersonEntity:
          Name:
            NameFull: Levin J
      – PersonEntity:
          Name:
            NameFull: Lopera F
      – PersonEntity:
          Name:
            NameFull: Roh J
      – PersonEntity:
          Name:
            NameFull: Rosa-Neto P
      – PersonEntity:
          Name:
            NameFull: Schofield PR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2025 Apr
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1474-4465
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: The Lancet. Neurology
              Type: main
ResultId 1