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Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

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Title: Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.
Authors: Shaw S; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Jiang W; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Rush J; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Dumont N; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Kim J; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Singh R; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Skepner A; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Khodier C; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Raffier C; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Murphy Z; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Yan N; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Krantz Family Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA., Schluter C; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Krantz Family Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA., Yu X; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Szuchnicki M; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Sathappa M; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Kahn J; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sperling AS; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wagner F; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., McKinney DC; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Gould AE; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Garvie CW; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Miller PG; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Krantz Family Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Source: IScience [iScience] 2025 Feb 20; Vol. 28 (3), pp. 112069. Date of Electronic Publication: 2025 Feb 20 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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