Role of glycosylation mutations at the N-terminal domain of SARS-CoV-2 XEC variant in immune evasion, cell-cell fusion, and spike stability.
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| Title: | Role of glycosylation mutations at the N-terminal domain of SARS-CoV-2 XEC variant in immune evasion, cell-cell fusion, and spike stability. |
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| Authors: | Li P; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA., Faraone JN; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, USA., Hsu CC; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA., Chamblee M; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA., Liu Y; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA., Zheng Y-M; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA., Xu Y; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.; Texas Therapeutic Institute, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA., Carlin C; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA., Horowitz JC; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine,The Ohio State University, Columbus, Ohio, USA.; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA., Mallampalli RK; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine,The Ohio State University, Columbus, Ohio, USA.; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA., Saif LJ; Center for Food Animal Health, Animal Sciences Department, OARDC, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Wooster, Ohio, USA.; Veterinary Preventive Medicine Department, College of Veterinary Medicine, The Ohio State University, Wooster, Ohio, USA.; Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA., Oltz EM; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J Solove Research Institute, Columbus, Ohio, USA., Jones D; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Li J; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA., Gumina RJ; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Bednash JS; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine,The Ohio State University, Columbus, Ohio, USA.; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA., Xu K; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.; Texas Therapeutic Institute, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA., Liu S-L; Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.; Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA.; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA. |
| Source: | Journal of virology [J Virol] 2025 Apr 15; Vol. 99 (4), pp. e0024225. Date of Electronic Publication: 2025 Mar 26. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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