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Hypertrophic Cardiomyopathy-Associated CRYABR123W Activates Calcineurin, Reduces Calcium Sequestration, and Alters the CRYAB Interactome and the Proteomic Response to Pathological Hypertrophy.

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Title: Hypertrophic Cardiomyopathy-Associated CRYABR123W Activates Calcineurin, Reduces Calcium Sequestration, and Alters the CRYAB Interactome and the Proteomic Response to Pathological Hypertrophy.
Authors: Thorkelsson A; MD Program, Tufts University School of Medicine, Boston, MA 02111, USA., Chou C; MD Program, Tufts University School of Medicine, Boston, MA 02111, USA., Tripp A; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA., Ali SA; Genetics, Molecular and Cellular Biology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA., Galper J; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA., Chin MT; MD Program, Tufts University School of Medicine, Boston, MA 02111, USA.; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.; Genetics, Molecular and Cellular Biology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 07; Vol. 26 (6). Date of Electronic Publication: 2025 Mar 07.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hypertrophic Cardiomyopathy-Associated CRYAB<superscript>R123W</superscript> Activates Calcineurin, Reduces Calcium Sequestration, and Alters the CRYAB Interactome and the Proteomic Response to Pathological Hypertrophy.
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  Data: <searchLink fieldCode="AU" term="%22Thorkelsson+A%22">Thorkelsson A</searchLink>; MD Program, Tufts University School of Medicine, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Chou+C%22">Chou C</searchLink>; MD Program, Tufts University School of Medicine, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Tripp+A%22">Tripp A</searchLink>; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Ali+SA%22">Ali SA</searchLink>; Genetics, Molecular and Cellular Biology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Galper+J%22">Galper J</searchLink>; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Chin+MT%22">Chin MT</searchLink>; MD Program, Tufts University School of Medicine, Boston, MA 02111, USA.; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.; Genetics, Molecular and Cellular Biology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
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  Data: <searchLink fieldCode="JN" term="%22101092791%22">International journal of molecular sciences</searchLink> [Int J Mol Sci] 2025 Mar 07; Vol. 26 (6). <i>Date of Electronic Publication: </i>2025 Mar 07.
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        Value: 10.3390/ijms26062383
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      – TitleFull: Hypertrophic Cardiomyopathy-Associated CRYABR123W Activates Calcineurin, Reduces Calcium Sequestration, and Alters the CRYAB Interactome and the Proteomic Response to Pathological Hypertrophy.
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