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Toxicological assessment of niga-ichigoside F1 and 2β,3β-19α-trihydroxyursolic acid derived from Rubus imperialis (Rosaceae): determining the safety using human peripheral blood mononuclear cells (PBMC).

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Title: Toxicological assessment of niga-ichigoside F1 and 2β,3β-19α-trihydroxyursolic acid derived from Rubus imperialis (Rosaceae): determining the safety using human peripheral blood mononuclear cells (PBMC).
Authors: Almeida-Terassi LM; Postgraduate Program in Health and Aging, Marilia Medical School (FAMEMA), Marilia Brazil., de Almeida LA; Faculty of Philosophy and Sciences, Speech and Hearing Therapy Department, São Paulo State University (UNESP), Marília, Brazil., Alves GR; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Vale do Itajaí University (UNIVALI), Itajaí, Brazil., Cechinel-Filho V; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Vale do Itajaí University (UNIVALI), Itajaí, Brazil., Niero R; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Vale do Itajaí University (UNIVALI), Itajaí, Brazil., de Mascarenhas Gaivão IO; Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, CECAV, Vila Real, Portugal., Mantovani MS; Department of General Biology, Londrina State University (UEL), Londrina, Brazil., Maistro EL; Postgraduate Program in Health and Aging, Marilia Medical School (FAMEMA), Marilia Brazil.; Faculty of Philosophy and Sciences, Speech and Hearing Therapy Department, São Paulo State University (UNESP), Marília, Brazil.
Source: Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2025; Vol. 88 (17), pp. 667-677. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100960995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2381-3504 (Electronic) Linking ISSN: 00984108 NLM ISO Abbreviation: J Toxicol Environ Health A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toxicological assessment of niga-ichigoside F1 and 2β,3β-19α-trihydroxyursolic acid derived from Rubus imperialis (Rosaceae): determining the safety using human peripheral blood mononuclear cells (PBMC).
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  Data: <searchLink fieldCode="AU" term="%22Almeida-Terassi+LM%22">Almeida-Terassi LM</searchLink>; Postgraduate Program in Health and Aging, Marilia Medical School (FAMEMA), Marilia Brazil.<br /><searchLink fieldCode="AU" term="%22de+Almeida+LA%22">de Almeida LA</searchLink>; Faculty of Philosophy and Sciences, Speech and Hearing Therapy Department, São Paulo State University (UNESP), Marília, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+GR%22">Alves GR</searchLink>; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Vale do Itajaí University (UNIVALI), Itajaí, Brazil.<br /><searchLink fieldCode="AU" term="%22Cechinel-Filho+V%22">Cechinel-Filho V</searchLink>; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Vale do Itajaí University (UNIVALI), Itajaí, Brazil.<br /><searchLink fieldCode="AU" term="%22Niero+R%22">Niero R</searchLink>; Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Vale do Itajaí University (UNIVALI), Itajaí, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Mascarenhas+Gaivão+IO%22">de Mascarenhas Gaivão IO</searchLink>; Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, CECAV, Vila Real, Portugal.<br /><searchLink fieldCode="AU" term="%22Mantovani+MS%22">Mantovani MS</searchLink>; Department of General Biology, Londrina State University (UEL), Londrina, Brazil.<br /><searchLink fieldCode="AU" term="%22Maistro+EL%22">Maistro EL</searchLink>; Postgraduate Program in Health and Aging, Marilia Medical School (FAMEMA), Marilia Brazil.; Faculty of Philosophy and Sciences, Speech and Hearing Therapy Department, São Paulo State University (UNESP), Marília, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22100960995%22">Journal of toxicology and environmental health. Part A</searchLink> [J Toxicol Environ Health A] 2025; Vol. 88 (17), pp. 667-677. <i>Date of Electronic Publication: </i>2025 Apr 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100960995 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2381-3504 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200984108%22">00984108 </searchLink><i>NLM ISO Abbreviation: </i>J Toxicol Environ Health A <i>Subsets: </i>MEDLINE
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        Value: 10.1080/15287394.2025.2484350
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      – TitleFull: Toxicological assessment of niga-ichigoside F1 and 2β,3β-19α-trihydroxyursolic acid derived from Rubus imperialis (Rosaceae): determining the safety using human peripheral blood mononuclear cells (PBMC).
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              Text: 2025
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