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Development of C646-Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300.

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Title: Development of C646-Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300.
Authors: Fiorentino F; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Spriano F; Faculty of Biomedical Sciences, Institute of Oncology Research, USI Bellinzona, 6500, Bellinzona, Switzerland., Tomaselli D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Risi G; Faculty of Biomedical Sciences, Institute of Oncology Research, USI Bellinzona, 6500, Bellinzona, Switzerland., Fabbrizi E; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy., Pecci V; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy., Nanni S; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.; Fondazione 'Policlinico Universitario A. Gemelli IRCCS', 00168, Rome, Italy., Bertoni F; Faculty of Biomedical Sciences, Institute of Oncology Research, USI Bellinzona, 6500, Bellinzona, Switzerland.; Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale Bellinzona, 6500, Bellinzona, Switzerland., Rotili D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.; Department of Science, 'Roma Tre' University, V.le G. Marconi 446, 00146, Rome, Italy.; Biostructures and Biosystems National Institute (INBB), Via dei Carpegna 19, 00165, Rome, Italy., Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Source: ChemMedChem [ChemMedChem] 2025 Jun 17; Vol. 20 (12), pp. e202400792. Date of Electronic Publication: 2025 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of C646-Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300.
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  Data: <searchLink fieldCode="AU" term="%22Fiorentino+F%22">Fiorentino F</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Spriano+F%22">Spriano F</searchLink>; Faculty of Biomedical Sciences, Institute of Oncology Research, USI Bellinzona, 6500, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tomaselli+D%22">Tomaselli D</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Risi+G%22">Risi G</searchLink>; Faculty of Biomedical Sciences, Institute of Oncology Research, USI Bellinzona, 6500, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fabbrizi+E%22">Fabbrizi E</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pecci+V%22">Pecci V</searchLink>; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nanni+S%22">Nanni S</searchLink>; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.; Fondazione 'Policlinico Universitario A. Gemelli IRCCS', 00168, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bertoni+F%22">Bertoni F</searchLink>; Faculty of Biomedical Sciences, Institute of Oncology Research, USI Bellinzona, 6500, Bellinzona, Switzerland.; Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale Bellinzona, 6500, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rotili+D%22">Rotili D</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.; Department of Science, 'Roma Tre' University, V.le G. Marconi 446, 00146, Rome, Italy.; Biostructures and Biosystems National Institute (INBB), Via dei Carpegna 19, 00165, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mai+A%22">Mai A</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
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