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Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats.

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Title: Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats.
Authors: Tonnele H; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Chen D; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Morillo F; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Garcia-Calleja J; Institute of Evolutionary Biology (CSIC-UPF), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Chitre AS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Johnson BB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sanches TM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Gonzalez A; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Kosciolek T; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., George AM; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA., Han W; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Holl K; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Horvath A; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Ishiwari K; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., King CP; Department of Psychology, University at Buffalo, NY, USA., Lamparelli AC; Department of Psychology, University at Buffalo, NY, USA., Martin CD; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., Martinez AG; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Netzley AH; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Tripi JA; Department of Psychology, University at Buffalo, NY, USA., Wang T; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Bosch E; Institute of Evolutionary Biology (CSIC-UPF), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Doris PA; Center for Human Genetics, Institute of Molecular Medicine, McGovern Medical School, University of Texas at Houston, TX, USA., Stegle O; European Molecular Biology Laboratory, Heidelberg, Germany., Chen H; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Flagel SB; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Meyer PJ; Department of Psychology, University at Buffalo, NY, USA., Richards JB; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., Robinson TE; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Woods LCS; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA., Polesskaya O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Knight R; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Department of Computer Science & Engineering, University of California San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, La Jolla, CA, San Diego, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Baud A; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 13. Date of Electronic Publication: 2025 Sep 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Center for Human Genetics, Institute of Molecular Medicine, McGovern Medical School, University of Texas at Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Stegle+O%22">Stegle O</searchLink>; European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Flagel+SB%22">Flagel SB</searchLink>; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+PJ%22">Meyer PJ</searchLink>; Department of Psychology, University at Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Richards+JB%22">Richards JB</searchLink>; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+TE%22">Robinson TE</searchLink>; Department of Psychology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Woods+LCS%22">Woods LCS</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Polesskaya+O%22">Polesskaya O</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Knight+R%22">Knight R</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Department of Computer Science & Engineering, University of California San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, La Jolla, CA, San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Palmer+AA%22">Palmer AA</searchLink>; 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