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Structural basis of the multiple ligand binding mechanisms of the P2X1 receptor.

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Title: Structural basis of the multiple ligand binding mechanisms of the P2X1 receptor.
Authors: Qiang YT; School of Pharmacy, Guizhou Medical University, Guizhou, 550025, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China., Wu PP; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Liu X; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Peng L; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China., Zhao LK; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China., Chen YT; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Zunyi Medical University, Zunyi, 563006, China., Gao ZB; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhao Q; School of Pharmacy, Guizhou Medical University, Guizhou, 550025, China. zhaoq@simm.ac.cn.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. zhaoq@simm.ac.cn.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. zhaoq@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. zhaoq@simm.ac.cn.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. zhaoq@simm.ac.cn.; School of Pharmacy, Zunyi Medical University, Zunyi, 563006, China. zhaoq@simm.ac.cn., Chen K; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. chenkun@simm.ac.cn.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. chenkun@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. chenkun@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Sep; Vol. 46 (9), pp. 2564-2573. Date of Electronic Publication: 2025 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Qiang+YT%22">Qiang YT</searchLink>; School of Pharmacy, Guizhou Medical University, Guizhou, 550025, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Wu+PP%22">Wu PP</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Peng+L%22">Peng L</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Zhao+LK%22">Zhao LK</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Chen+YT%22">Chen YT</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Zunyi Medical University, Zunyi, 563006, China.<br /><searchLink fieldCode="AU" term="%22Gao+ZB%22">Gao ZB</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; School of Pharmacy, Guizhou Medical University, Guizhou, 550025, China. zhaoq@simm.ac.cn.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. zhaoq@simm.ac.cn.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. zhaoq@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. zhaoq@simm.ac.cn.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. zhaoq@simm.ac.cn.; School of Pharmacy, Zunyi Medical University, Zunyi, 563006, China. zhaoq@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. chenkun@simm.ac.cn.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. chenkun@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. chenkun@simm.ac.cn.
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        Value: 10.1038/s41401-025-01512-y
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              M: 09
              Text: 2025 Sep
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              Y: 2025
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