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CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer.

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Title: CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer.
Authors: Chia S; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore. Electronic address: chiasm1@gis.a-star.edu.sg., Wen Seow JJ; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Peres da Silva R; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Suphavilai C; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Shirgaonkar N; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Murata-Hori M; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Zhang X; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Yong EY; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Pan J; National Cancer Centre, Singapore, Singapore., Thangavelu MT; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Experimental Drug Development Centre (EDDC), A∗STAR, Singapore, Singapore., Periyasamy G; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Experimental Drug Development Centre (EDDC), A∗STAR, Singapore, Singapore., Yap A; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Anand P; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Muliaditan D; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chan YS; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China., Siyu W; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Yong CW; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Hong N; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Ran G; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Sim NL; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Guo YA; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Yi Teh AX; National Cancer Centre, Singapore, Singapore., Wei Ling CC; National Cancer Centre, Singapore, Singapore., Wei Tan EK; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Pei Cherylin FW; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Chang M; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Han S; National Cancer Centre, Singapore, Singapore., Seow-En I; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Chen Hui LR; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Hsia Gan AH; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Yap CK; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Ng HH; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Skanderup AJ; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Chinswangwatanakul V; Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Cancer Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Riansuwan W; Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Trakarnsanga A; Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Pithukpakorn M; Siriraj Genomics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol, Bangkok, Thailand., Tanjak P; Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Cancer Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Chaiboonchoe A; Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Park D; Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Kim DK; Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Iyer NG; National Cancer Centre, Singapore, Singapore., Tsantoulis P; Hôpitaux Universitaires de Genève, University of Geneva, Geneva, Switzerland., Tejpar S; Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium., Kim JE; R&D center PODO Therapeutics Co. 338 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13493, Republic of Korea., Kim TI; R&D center PODO Therapeutics Co. 338 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13493, Republic of Korea; Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Sampattavanich S; Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Tan IB; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; National Cancer Centre, Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore. Electronic address: iaintan@duke-nus.edu.sg., Nagarajan N; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: nagarajann@gis.a-star.edu.sg., DasGupta R; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; CRUK Scotland Institute, School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: ramanuj.dasgupta@glasgow.ac.uk.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Apr 15; Vol. 6 (4), pp. 102053. Date of Electronic Publication: 2025 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chia+S%22">Chia S</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore. Electronic address: chiasm1@gis.a-star.edu.sg.<br /><searchLink fieldCode="AU" term="%22Wen+Seow+JJ%22">Wen Seow JJ</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Peres+da+Silva+R%22">Peres da Silva R</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Suphavilai+C%22">Suphavilai C</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Shirgaonkar+N%22">Shirgaonkar N</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Murata-Hori+M%22">Murata-Hori M</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yong+EY%22">Yong EY</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; National Cancer Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Thangavelu+MT%22">Thangavelu MT</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Experimental Drug Development Centre (EDDC), A∗STAR, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Periyasamy+G%22">Periyasamy G</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Experimental Drug Development Centre (EDDC), A∗STAR, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yap+A%22">Yap A</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Anand+P%22">Anand P</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Muliaditan+D%22">Muliaditan D</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+YS%22">Chan YS</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Siyu+W%22">Siyu W</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yong+CW%22">Yong CW</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hong+N%22">Hong N</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ran+G%22">Ran G</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sim+NL%22">Sim NL</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Guo+YA%22">Guo YA</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yi+Teh+AX%22">Yi Teh AX</searchLink>; National Cancer Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wei+Ling+CC%22">Wei Ling CC</searchLink>; 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