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Adipose Tissue Macrophages in Metabolic Dysfunction-Associated Steatohepatitis Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice.

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Title: Adipose Tissue Macrophages in Metabolic Dysfunction-Associated Steatohepatitis Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice.
Authors: Rohm TV; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: trohm@health.ucsd.edu., Dos Reis FCG; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Cunha E Rocha K; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Isaac R; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Strayer S; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Murphy C; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Bandyopadhyay G; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Gao H; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Ganguly S; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Center for Metabolic and Liver Diseases, Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California., Nguyen T; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Wang J; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Youhanna JE; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Pack D; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Liu X; Department of Surgery, University of California San Diego, School of Medicine, La Jolla, California., Kim HY; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Department of Surgery, University of California San Diego, School of Medicine, La Jolla, California; College of Pharmacy, Dankook University, Cheonan, Chungnam, Republic of Korea., Jeelani I; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Dhar D; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Center for Metabolic and Liver Diseases, Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California., Kisseleva T; Department of Surgery, University of California San Diego, School of Medicine, La Jolla, California., Ying W; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California., Olefsky JM; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: jolefsky@health.ucsd.edu.
Source: Gastroenterology [Gastroenterology] 2025 Sep; Vol. 169 (4), pp. 691-704.e9. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rohm+TV%22">Rohm TV</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: trohm@health.ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Dos+Reis+FCG%22">Dos Reis FCG</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Cunha+E+Rocha+K%22">Cunha E Rocha K</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Isaac+R%22">Isaac R</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Strayer+S%22">Strayer S</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Murphy+C%22">Murphy C</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Bandyopadhyay+G%22">Bandyopadhyay G</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Ganguly+S%22">Ganguly S</searchLink>; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Center for Metabolic and Liver Diseases, Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Youhanna+JE%22">Youhanna JE</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Pack+D%22">Pack D</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Surgery, University of California San Diego, School of Medicine, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Kim+HY%22">Kim HY</searchLink>; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Department of Surgery, University of California San Diego, School of Medicine, La Jolla, California; College of Pharmacy, Dankook University, Cheonan, Chungnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeelani+I%22">Jeelani I</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Dhar+D%22">Dhar D</searchLink>; Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California; Center for Metabolic and Liver Diseases, Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Kisseleva+T%22">Kisseleva T</searchLink>; Department of Surgery, University of California San Diego, School of Medicine, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Ying+W%22">Ying W</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Olefsky+JM%22">Olefsky JM</searchLink>; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: jolefsky@health.ucsd.edu.
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