Astrocytic RNA editing regulates the host immune response to alpha-synuclein.

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Title: Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
Authors: D'Sa K; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Choi ML; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Brain & Cognitive Sciences, KAIST, 921 Dehak-ro, Daejeon, Republic of Korea., Wagen AZ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Setó-Salvia N; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Kopach O; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.; Neuroscience and Cell Biology Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK., Evans JR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Rodrigues M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute at The University of Cambridge, Cambridge CB2 0AH, UK., Lopez-Garcia P; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Lachica J; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Clarke BE; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Department of Neuromuscular Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK., Singh J; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Ghareeb A; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; Applied Biotechnology Lab, The Francis Crick Institute, London NW1 1AT, UK., Bayne J; Applied Biotechnology Lab, The Francis Crick Institute, London NW1 1AT, UK.; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK., Grant-Peters M; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Garcia-Ruiz S; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Chen Z; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Rodriques S; Applied Biotechnology Lab, The Francis Crick Institute, London NW1 1AT, UK.; FutureHouse, 1405 Minnesota Street, San Francisco, CA 94107, USA., Athauda D; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Gustavsson EK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Gagliano Taliun SA; Montréal Heart Institute, Montréal, QC, Canada.; Department of Medicine and Department of Neurosciences, Université de Montréal, Montréal, QC, Canada., Toomey C; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Reynolds RH; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK., Young G; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; MRC Laboratory of Medical Sciences, London W12 0HS, UK., Strohbuecker S; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Warner T; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Rusakov DA; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Patani R; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Department of Neuromuscular Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK., Bryant C; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK., Klenerman DA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute at The University of Cambridge, Cambridge CB2 0AH, UK., Gandhi S; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Ryten M; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.; UK Dementia Research Institute at The University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
Source: Science advances [Sci Adv] 2025 Apr 11; Vol. 11 (15), pp. eadp8504. Date of Electronic Publication: 2025 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
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  Data: <searchLink fieldCode="AU" term="%22D'Sa+K%22">D'Sa K</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Choi+ML%22">Choi ML</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Brain & Cognitive Sciences, KAIST, 921 Dehak-ro, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Wagen+AZ%22">Wagen AZ</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Setó-Salvia+N%22">Setó-Salvia N</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Kopach+O%22">Kopach O</searchLink>; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.; Neuroscience and Cell Biology Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Evans+JR%22">Evans JR</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Rodrigues+M%22">Rodrigues M</searchLink>; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute at The University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Lopez-Garcia+P%22">Lopez-Garcia P</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Lachica+J%22">Lachica J</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+BE%22">Clarke BE</searchLink>; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Department of Neuromuscular Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Singh+J%22">Singh J</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Ghareeb+A%22">Ghareeb A</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; Applied Biotechnology Lab, The Francis Crick Institute, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Bayne+J%22">Bayne J</searchLink>; Applied Biotechnology Lab, The Francis Crick Institute, London NW1 1AT, UK.; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.<br /><searchLink fieldCode="AU" term="%22Grant-Peters+M%22">Grant-Peters M</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Garcia-Ruiz+S%22">Garcia-Ruiz S</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Rodriques+S%22">Rodriques S</searchLink>; Applied Biotechnology Lab, The Francis Crick Institute, London NW1 1AT, UK.; FutureHouse, 1405 Minnesota Street, San Francisco, CA 94107, USA.<br /><searchLink fieldCode="AU" term="%22Athauda+D%22">Athauda D</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Gustavsson+EK%22">Gustavsson EK</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Gagliano+Taliun+SA%22">Gagliano Taliun SA</searchLink>; Montréal Heart Institute, Montréal, QC, Canada.; Department of Medicine and Department of Neurosciences, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Toomey+C%22">Toomey C</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Reynolds+RH%22">Reynolds RH</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.<br /><searchLink fieldCode="AU" term="%22Young+G%22">Young G</searchLink>; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; MRC Laboratory of Medical Sciences, London W12 0HS, UK.<br /><searchLink fieldCode="AU" term="%22Strohbuecker+S%22">Strohbuecker S</searchLink>; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Warner+T%22">Warner T</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Rusakov+DA%22">Rusakov DA</searchLink>; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Patani+R%22">Patani R</searchLink>; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Department of Neuromuscular Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Bryant+C%22">Bryant C</searchLink>; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.<br /><searchLink fieldCode="AU" term="%22Klenerman+DA%22">Klenerman DA</searchLink>; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute at The University of Cambridge, Cambridge CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Gandhi+S%22">Gandhi S</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Ryten+M%22">Ryten M</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.; UK Dementia Research Institute at The University of Cambridge, Cambridge CB2 0AH, UK.; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
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