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ctDNA can detect minimal residual disease in curative treated non-small cell lung cancer patients using a tumor agnostic approach.

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Title: ctDNA can detect minimal residual disease in curative treated non-small cell lung cancer patients using a tumor agnostic approach.
Authors: Rosenlund L; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Guldbrandsen K; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Ahlborn LB; Department of Genomic Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Bloch M; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Skougaard K; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark; Department of Oncology, University Hospital of Southern Denmark - Roskilde, Denmark., Albrecht-Beste E; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nellemann HM; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark., Krakauer M; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Gørtz PM; Department of Nuclear Medicine, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark., Fledelius J; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark., Nielsen AL; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Holdgaard PC; Department of Nuclear Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark., Nielsen SS; Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark., Grüner JM; Department of Clinical Physiology and Nuclear Medicine, Zealand University Hospital - Køge, Denmark., Højsgaard A; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark., Petersen RH; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Møller LB; Department of Cardiothoracic Surgery, Aalborg University Hospital, Aalborg, Denmark., Dahl M; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Zealand University Hospital - Køge, Denmark., Frank MS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Denmark., Ehlers JH; Department of Oncology, University Hospital of Southern Denmark - Roskilde, Denmark; Medicin 2, Holbæk Hospital, Holbæk, Denmark., Saghir Z; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Section of Pulmonary Medicine, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark., Pøhl M; Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Borissova S; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Land LH; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Kristiansen C; Department of Oncology, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark., McCulloch T; Department of Oncology, Aalborg University Hospital, Aalborg Denmark; Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark., Mortensen LS; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Christophersen MS; Department of Respiratory Disease, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark; Department of Emergency Medicine, Regional Hospital Horsens, Horsens, Denmark., Hilberg O; Department of Respiratory Disease, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Rasmussen TL; Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark., Simonsen Schwaner SH; Department of Respiratory Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Laursen CB; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark; Odense Respiratory Research Unit (ODIN), Department of Clinical Medicine, University of Southern Denmark, Odense, Denmark., Bodtger U; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Respiratory Research Unit PLUZ, Department of Respiratory Medicine, Zealand University Hospital - Næstved, Denmark., Lonsdale MN; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Meyer CN; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Zealand University Hospital - Roskilde, Denmark., Gerke O; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Mortensen J; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rasmussen TR; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Respiratory Medicine and Allergy, Aarhus University Hospital, Aarhus, Denmark., Hjorthaug K; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark., Larsen KR; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Respiratory Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Meldgaard P; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Fischer BM; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sorensen BS; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: boesoere@rm.dk.
Source: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2025 May; Vol. 203, pp. 108528. Date of Electronic Publication: 2025 Apr 04.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ctDNA can detect minimal residual disease in curative treated non-small cell lung cancer patients using a tumor agnostic approach.
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  Data: <searchLink fieldCode="AU" term="%22Rosenlund+L%22">Rosenlund L</searchLink>; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Guldbrandsen+K%22">Guldbrandsen K</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ahlborn+LB%22">Ahlborn LB</searchLink>; Department of Genomic Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bloch+M%22">Bloch M</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Skougaard+K%22">Skougaard K</searchLink>; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark; Department of Oncology, University Hospital of Southern Denmark - Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Albrecht-Beste+E%22">Albrecht-Beste E</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nellemann+HM%22">Nellemann HM</searchLink>; Department of Radiology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Krakauer+M%22">Krakauer M</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gørtz+PM%22">Gørtz PM</searchLink>; Department of Nuclear Medicine, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.<br /><searchLink fieldCode="AU" term="%22Fledelius+J%22">Fledelius J</searchLink>; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+AL%22">Nielsen AL</searchLink>; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Holdgaard+PC%22">Holdgaard PC</searchLink>; Department of Nuclear Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+SS%22">Nielsen SS</searchLink>; Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Grüner+JM%22">Grüner JM</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Zealand University Hospital - Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Højsgaard+A%22">Højsgaard A</searchLink>; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+RH%22">Petersen RH</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Møller+LB%22">Møller LB</searchLink>; Department of Cardiothoracic Surgery, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Dahl+M%22">Dahl M</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Zealand University Hospital - Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Frank+MS%22">Frank MS</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Denmark.<br /><searchLink fieldCode="AU" term="%22Ehlers+JH%22">Ehlers JH</searchLink>; Department of Oncology, University Hospital of Southern Denmark - Roskilde, Denmark; Medicin 2, Holbæk Hospital, Holbæk, Denmark.<br /><searchLink fieldCode="AU" term="%22Saghir+Z%22">Saghir Z</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Section of Pulmonary Medicine, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.<br /><searchLink fieldCode="AU" term="%22Pøhl+M%22">Pøhl M</searchLink>; Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Borissova+S%22">Borissova S</searchLink>; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Land+LH%22">Land LH</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Kristiansen+C%22">Kristiansen C</searchLink>; Department of Oncology, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22McCulloch+T%22">McCulloch T</searchLink>; Department of Oncology, Aalborg University Hospital, Aalborg Denmark; Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Mortensen+LS%22">Mortensen LS</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Christophersen+MS%22">Christophersen MS</searchLink>; Department of Respiratory Disease, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark; Department of Emergency Medicine, Regional Hospital Horsens, Horsens, Denmark.<br /><searchLink fieldCode="AU" term="%22Hilberg+O%22">Hilberg O</searchLink>; Department of Respiratory Disease, University Hospital of Southern Denmark, Lillebaelt Hospital - Vejle, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Rasmussen+TL%22">Rasmussen TL</searchLink>; Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Simonsen+Schwaner+SH%22">Simonsen Schwaner SH</searchLink>; Department of Respiratory Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Laursen+CB%22">Laursen CB</searchLink>; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark; Odense Respiratory Research Unit (ODIN), Department of Clinical Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Bodtger+U%22">Bodtger U</searchLink>; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Respiratory Research Unit PLUZ, Department of Respiratory Medicine, Zealand University Hospital - Næstved, Denmark.<br /><searchLink fieldCode="AU" term="%22Lonsdale+MN%22">Lonsdale MN</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Meyer+CN%22">Meyer CN</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Zealand University Hospital - Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Gerke+O%22">Gerke O</searchLink>; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Mortensen+J%22">Mortensen J</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rasmussen+TR%22">Rasmussen TR</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Respiratory Medicine and Allergy, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Hjorthaug+K%22">Hjorthaug K</searchLink>; Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+KR%22">Larsen KR</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Respiratory Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Meldgaard+P%22">Meldgaard P</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Fischer+BM%22">Fischer BM</searchLink>; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sorensen+BS%22">Sorensen BS</searchLink>; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: boesoere@rm.dk.
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