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Inhibition of RANKL is critical for accurate assessment of anti-drug antibody incidence to denosumab in clinical studies.

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Title: Inhibition of RANKL is critical for accurate assessment of anti-drug antibody incidence to denosumab in clinical studies.
Authors: Miller MJ; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America. Electronic address: millermj@amgen.com., Kroenke MA; Clinical Immunology, Amgen, Thousand Oaks, CA 91320, United States of America., Barger T; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America., Manning MS; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America., Sohn W; Clinical Pharmacology Modeling and Simulation, Amgen, Thousand Oaks, CA 91320, United States of America., Graham K; Large Molecule Discovery & Research Data Science, Amgen, Thousand Oaks, CA 91320, United States of America., Mytych DT; Clinical Immunology, Amgen, Thousand Oaks, CA 91320, United States of America., Gupta S; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America.
Source: Journal of immunological methods [J Immunol Methods] 2025 May; Vol. 540, pp. 113864. Date of Electronic Publication: 2025 Apr 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1305440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7905 (Electronic) Linking ISSN: 00221759 NLM ISO Abbreviation: J Immunol Methods Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of RANKL is critical for accurate assessment of anti-drug antibody incidence to denosumab in clinical studies.
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  Data: <searchLink fieldCode="AU" term="%22Miller+MJ%22">Miller MJ</searchLink>; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America. Electronic address: millermj@amgen.com.<br /><searchLink fieldCode="AU" term="%22Kroenke+MA%22">Kroenke MA</searchLink>; Clinical Immunology, Amgen, Thousand Oaks, CA 91320, United States of America.<br /><searchLink fieldCode="AU" term="%22Barger+T%22">Barger T</searchLink>; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America.<br /><searchLink fieldCode="AU" term="%22Manning+MS%22">Manning MS</searchLink>; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America.<br /><searchLink fieldCode="AU" term="%22Sohn+W%22">Sohn W</searchLink>; Clinical Pharmacology Modeling and Simulation, Amgen, Thousand Oaks, CA 91320, United States of America.<br /><searchLink fieldCode="AU" term="%22Graham+K%22">Graham K</searchLink>; Large Molecule Discovery & Research Data Science, Amgen, Thousand Oaks, CA 91320, United States of America.<br /><searchLink fieldCode="AU" term="%22Mytych+DT%22">Mytych DT</searchLink>; Clinical Immunology, Amgen, Thousand Oaks, CA 91320, United States of America.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Translational Safety and Bioanalytical Sciences, Amgen, Thousand Oaks, CA 91320, United States of America.
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  Data: <searchLink fieldCode="JN" term="%221305440%22">Journal of immunological methods</searchLink> [J Immunol Methods] 2025 May; Vol. 540, pp. 113864. <i>Date of Electronic Publication: </i>2025 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1305440 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7905 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221759%22">00221759 </searchLink><i>NLM ISO Abbreviation: </i>J Immunol Methods <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jim.2025.113864
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      – Code: eng
        Text: English
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      – TitleFull: Inhibition of RANKL is critical for accurate assessment of anti-drug antibody incidence to denosumab in clinical studies.
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              Text: 2025 May
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