Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.

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Bibliographic Details
Title: Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.
Authors: Wang A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Monticelli SR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.; Geneva Foundation, Tacoma, Washington, USA., Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Kuehne AI; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA., Bakken RR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA., Middlecamp M; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Weingart M; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA., Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Berrigan JL; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., West BR; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Bikash CR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA., Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Source: MBio [mBio] 2025 May 14; Vol. 16 (5), pp. e0320224. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2150-7511
DOI:10.1128/mbio.03202-24